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San Diego Padres vs. Pittsburgh Pirates: Preview, Predictions and Picks for May 4, 2025

Updated on:
May 4, 2025 2:40 PM
The San Diego Padres, riding a two-game win streak, look to keep their momentum alive as they face off against the Pittsburgh Pirates on Sunday, May 4th at 1:35 PM. The Padres, with a 21-11 record, will aim to capitalize on the Pirates' 7-11 home record at PNC Park, while also improving their own 7-7 road record. Can the Pirates break their spell and take down the second-place Padres in the NL West?
San Diego Padres vs Pittsburgh Pirates

Current Odds

SD
PIT
Over
6.0
+104
Under
5.5
+125
SD
-3.5
-169
PIT
+1.5
+625
SD
ML
-2800
PIT
ML
+1900

Padres vs Pirates statistics

Stat Padres Pirates
Hits 269 (Tied-15th) 251 (24th)
Batting Average .259 (3rd) .223 (27th)
Runs Batted In 118 (22nd) 112 (26th)
Runs 129 (18th) 114 (27th)
Home Runs 28 (Tied-21st) 25 (28th)
Walks 101 (Tied-21st) 125 (Tied-7th)
Stolen Bases 29 (10th) 39 (Tied-4th)
Strikeouts 219 (1st) 287 (24th)
Pitches 4425 (30th) 5034 (6th)

Pittsburgh Pirates recent games

Game Date Opponent Result Score
5/3/25 vs San Diego Padres L 2-1
5/2/25 vs San Diego Padres L 9-4
5/1/25 vs Chicago Cubs L 8-3
4/30/25 vs Chicago Cubs W 4-3
4/29/25 vs Chicago Cubs L 9-0

San Diego Padres recent games

Game Date Opponent Result Score
5/3/25 @ Pittsburgh Pirates W 2-1
5/2/25 @ Pittsburgh Pirates W 9-4
4/30/25 vs San Francisco Giants W 5-3
4/29/25 vs San Francisco Giants W 7-4
4/27/25 vs Tampa Bay Rays L 4-2

Pittsburgh Pirates injuries

  • Dennis Santana (RP): Bereavement
  • Sean Sullivan (SP): Day-To-Day
  • Spencer Horwitz (1B): 10-Day-IL
  • Burch Smith (RP): Day-To-Day
  • Endy Rodriguez (1B): 10-Day-IL

San Diego Padres injuries

  • Jackson Merrill (CF): 10-Day-IL
  • Sean Reynolds (RP): 15-Day-IL
  • Ethan Salas (C): Day-To-Day
  • Jake Cronenworth (2B): 10-Day-IL
  • Mason McCoy (SS): 10-Day-IL

Padres vs Pirates game info

Type Info
Venue PNC Park
Location Pittsburgh, Pennsylvania
First pitch Sun 1:35 PM
Temperature 70°
Chance of Rain 34%

Padres vs Pirates predictions

As the San Diego Padres gear up to face the Pittsburgh Pirates, all eyes will be on Fernando Tatis Jr., who’s been a force to be reckoned with so far this season. Batting average? A fantastic .342. Home runs? Eight, with a solid projection to add at least another one to his tally in this game, given his recent form at the plate. We've also got Stephen Kolek stepping up as the probable starting pitcher. While his stats show room for improvement, he’s shown potential to throw some impressive innings, with a projected four or five innings on the mound. Another star to watch out for in this matchup is Manny Machado. He's expected to be consistent, contributing with good control and solid contact; you might just see him punching in an extra RBI or two.

Switching focus over to the Pittsburgh Pirates, Oneil Cruz is poised to keep swinging for the fences. With eight homers to date, he's got the raw power to potentially add another homer to his name, perhaps translating to more runs on the scoreboard for the Pirates. Meanwhile, Isiah Kiner-Falefa, though currently sidelined with a hamstring strain, has had a commendable batting average of .280. His absence leaves a gap, but players like Andrew McCutchen could step up to the plate and make things exciting, while Joey Bart might slide in with a couple of key hits. Expecting Andrew Heaney to take the mound, his pitching today could either be the Pirates’ ace in the hole or, well, a gamble, depending on how he handles the Padres’ batting lineup.

Now, looking at the game overall, it's easy to see this as a heated contest between two MLB teams with something to prove. The Padres come into it with a sturdy record, smelling the opportunity to extend their win streak, and you can't help but think they'll hold the edge over the Pirates. Given their lineup's strength and players like Tatis Jr. heating up, I’d say the Padres are the favorites. However, the Pirates have some wild cards up their sleeves. It'll come down to who steps up when it matters most, but my money? I'd lean towards the Padres continuing their upward trajectory, clinching another W. What about you? Any gut feelings for the underdog Pirates pulling an upset?

Pittsburgh Pirates

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