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Chicago White Sox vs. Chicago Cubs: Preview, Predictions and Picks for May 17, 2025

Updated on:
May 18, 2025 1:52 AM
The Chicago Cubs, fresh off a win and riding a 26-19 overall record, welcome their crosstown rivals, the Chicago White Sox, to Wrigley Field on Saturday, May 17 at 2:20 PM. The Cubs are looking to build on their momentum, having already taken the lead in the regular season series. Following a strong 4-hit performance from Crow-Armstrong, the Cubs aim to capitalize on the White Sox's struggling road record.
Chicago White Sox vs Chicago Cubs

Current Odds

CHW
CHC
Over
8.0
-105
Under
8.5
-125
CHW
+1.5
+115
CHC
-1.5
-120
CHW
ML
+261
CHC
ML
-263

White Sox vs Cubs statistics

Stat White Sox Cubs
Hits 316 (28th) 395 (Tied-6th)
Batting Average .217 (28th) .253 (10th)
Runs Batted In 147 (28th) 252 (1st)
Runs 152 (28th) 257 (2nd)
Home Runs 34 (28th) 64 (3rd)
Walks 143 (17th) 170 (Tied-5th)
Stolen Bases 35 (Tied-14th) 51 (Tied-2nd)
Strikeouts 379 (19th) 361 (12th)
Pitches 6350 (20th) 6924 (2nd)

Chicago Cubs recent games

Game Date Opponent Result Score
5/16/25 vs Chicago White Sox W 13-3
5/14/25 vs Miami Marlins L 3-1
5/13/25 vs Miami Marlins W 5-4
5/12/25 vs Miami Marlins W 5-2
5/11/25 @ New York Mets L 6-2

Chicago White Sox recent games

Game Date Opponent Result Score
5/16/25 @ Chicago Cubs L 13-3
5/15/25 @ Cincinnati Reds L 7-1
5/14/25 @ Cincinnati Reds W 4-2
5/13/25 @ Cincinnati Reds W 5-1 F/10
5/11/25 vs Miami Marlins W 4-2

Chicago Cubs injuries

  • Ryan Brasier (RP): 15-Day-IL
  • Tyson Miller (RP): 60-Day-IL
  • Ian Happ (LF): 10-Day-IL
  • Shota Imanaga (SP): 15-Day-IL
  • Brandon Birdsell (RP): Day-To-Day

Chicago White Sox injuries

  • Tyler Gilbert (RP): Day-To-Day
  • Brandon Drury (2B): Day-To-Day
  • Korey Lee (C): 10-Day-IL
  • Mike Tauchman (RF): 10-Day-IL
  • Austin Slater (RF): 10-Day-IL

White Sox vs Cubs game info

Type Info
Venue Wrigley Field
Location Chicago, Illinois
First pitch Sat 2:20 PM
Temperature 62°
Chance of Rain 7%

White Sox vs Cubs predictions

Looking at the Chicago White Sox lineup heading into Wrigley, there are a few names that might surprise you with their potential impact. Lenyn Sosa has quietly been one of the more reliable bats in the order, and I wouldn’t be shocked to see him add another multi-hit game to his resume—his patient approach means he could easily reach base a couple of times and be a catalyst in the lineup. Luis Robert’s performance will be worth watching too; if he can get on base and use his speed, the White Sox might finally put some pressure on the basepaths. And don’t sleep on Tim Elko, a guy who’s shown flashes of pop and has the ability to deliver with runners in scoring position—could this be one of those nights he breaks through?

Swinging over to the other side of the diamond, these Chicago Cubs are rolling for a reason, and you can see why when you glance at the guys in their lineup. All eyes are on Pete Crow-Armstrong after his four-hit outburst, and it’d be no surprise if he rides that hot streak into tonight for an extra-base knock or two. Seiya Suzuki’s been a force in the heart of the order all year, so I’m expecting him to stay locked in and maybe drive in a couple more runs. And keep an eye on Michael Busch—he’s quietly getting on base, and tonight feels like the kind of matchup where he could do some real damage, especially with the Cubs’ offense firing on all cylinders.

Honestly, after sizing up these squads, it feels like the Cubs just have too much firepower, especially at home. Their lineup is getting on base, swiping bags, and finding ways to score at the top of the league, while the White Sox are still searching for answers at the plate. With Matthew Boyd on the mound facing a White Sox lineup struggling to find rhythm, it’s tough not to lean toward the Cubs grabbing another win in this crosstown rivalry. What do you think—can the South Siders pull off an upset at Wrigley, or is it all Cubbies tonight?

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