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Chicago White Sox vs. Chicago Cubs: Preview, Predictions and Picks for May 18, 2025

Updated on:
May 18, 2025 3:53 PM
The Chicago White Sox aim to snap a three-game road skid as they face off against their crosstown rivals, the Chicago Cubs, on Sunday at 2:20 PM. The White Sox will look to even the season series, currently led by the Cubs 2-0, at Wrigley Field. The Cubs, sitting atop the NL Central at 27-19, will look to continue their strong home form against the struggling White Sox.
Chicago White Sox vs Chicago Cubs

Current Odds

CHW
CHC
Over
7.5
+360
Under
7.5
-388
CHW
+4.5
+390
CHC
-4.5
-455
CHW
ML
+14000
CHC
ML
-10000

White Sox vs Cubs statistics

Stat White Sox Cubs
Hits 322 (29th) 404 (Tied-5th)
Batting Average .216 (30th) .253 (10th)
Runs Batted In 150 (29th) 259 (1st)
Runs 155 (28th) 264 (2nd)
Home Runs 36 (28th) 65 (3rd)
Walks 144 (18th) 181 (2nd)
Stolen Bases 37 (14th) 57 (2nd)
Strikeouts 391 (21st) 368 (12th)
Pitches 6497 (20th) 7083 (3rd)

Chicago Cubs recent games

Game Date Opponent Result Score
5/17/25 vs Chicago White Sox W 7-3
5/16/25 vs Chicago White Sox W 13-3
5/14/25 vs Miami Marlins L 3-1
5/13/25 vs Miami Marlins W 5-4
5/12/25 vs Miami Marlins W 5-2

Chicago White Sox recent games

Game Date Opponent Result Score
5/17/25 @ Chicago Cubs L 7-3
5/16/25 @ Chicago Cubs L 13-3
5/15/25 @ Cincinnati Reds L 7-1
5/14/25 @ Cincinnati Reds W 4-2
5/13/25 @ Cincinnati Reds W 5-1 F/10

Chicago Cubs injuries

  • Ryan Brasier (RP): 15-Day-IL
  • Tyson Miller (RP): 60-Day-IL
  • Ian Happ (LF): 10-Day-IL
  • Shota Imanaga (SP): 15-Day-IL
  • Brandon Birdsell (RP): Day-To-Day

Chicago White Sox injuries

  • Brandon Drury (2B): Day-To-Day
  • Korey Lee (C): 10-Day-IL
  • Mike Tauchman (RF): 10-Day-IL
  • Austin Slater (RF): 10-Day-IL
  • Fraser Ellard (RP): 15-Day-IL

White Sox vs Cubs game info

Type Info
Venue Wrigley Field
Location Chicago, Illinois
First pitch Sun 2:20 PM
Temperature 55°
Chance of Rain 0%

White Sox vs Cubs predictions

Looking at the Chicago White Sox lineup, it’s definitely a tough climb as they roll into Wrigley trying to shake off a three-game road slide. With Jonathan Cannon getting the start on the mound, I’m expecting he’ll give the Sox a solid but not overpowering outing—around five innings with a few earned runs scattered in, and maybe three or four strikeouts as he tries to keep a potent Cubs lineup in check. At the plate, Lenyn Sosa has quietly been their most consistent hitter, and I wouldn’t be surprised if he ropes a couple base hits and finds a way to get on the board. Luis Robert and Miguel Vargas both have the pop to put a charge in the ball, so don’t sleep on either making a little noise, but the real challenge will be whether the lineup can actually cash in with runners on base.

The Chicago Cubs, on the other hand, bring a lineup that’s just plain rolling right now. You can practically pencil in Pete Crow-Armstrong for a multi-hit game and at least a shot at going yard, given how hot he’s been in May. He’s been the straw stirring the Cubs offense, leading in every major category. Colin Rea is set to take the ball, and he’s been pretty steady at home—look for him to give six innings or so, with a few runners reaching but not a ton of damage. Around Crow-Armstrong, guys like Nico Hoerner and Seiya Suzuki are a headache on the basepaths and are more than capable of turning a walk or single into a run with their speed and aggressive baserunning. With Rea’s consistency and this offense clicking, there’s real potential for the Cubs to put up numbers early.

All things considered, it feels like the deck is stacked for the Cubs. The White Sox have the odds and history working against them, and with a lineup that’s struggled to string together hits, their margin for error is thin. The Cubs just have too much firepower in both the lineup and bullpen, and playing at Wrigley only boosts their confidence. Unless something truly unexpected happens, I like the Cubs to keep the good times rolling and send the White Sox packing with another tough road loss. What about you—can you see any path where Chicago’s South Siders flip the script?

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