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St. Louis Cardinals vs. Chicago Cubs: Preview, Predictions and Picks for July 5, 2025

Updated on:
Jul 5, 2025 10:23 AM
The Chicago Cubs, riding high on a 53-35 record and 29-15 home mark, look to build on their 1-0 series lead against the St. Louis Cardinals at Wrigley Field on Saturday. The Cardinals, fresh off a thrilling 3-home run performance from Dylan Carlson, aim to even the series despite their 21-25 road record. The matchup is set for a 2:20 PM start on July 5, 2025.
St. Louis Cardinals vs Chicago Cubs

Current Odds

STL
CHC
Over
11.5
+126
Under
10.5
+113
STL
+1.0
-105
CHC
-1.5
+141
STL
ML
+148
CHC
ML
-147

Cardinals vs Cubs statistics

Stat Cardinals Cubs
Hits 757 (12th) 780 (2nd)
Batting Average .251 (12th) .256 (6th)
Runs Batted In 386 (Tied-11th) 466 (2nd)
Runs 406 (10th) 475 (2nd)
Home Runs 88 (Tied-19th) 133 (3rd)
Walks 281 (Tied-18th) 304 (Tied-6th)
Stolen Bases 47 (Tied-22nd) 102 (2nd)
Strikeouts 689 (7th) 685 (6th)
Pitches 13059 (9th) 13260 (6th)

Chicago Cubs recent games

Game Date Opponent Result Score
7/4/25 vs St. Louis Cardinals W 11-3
7/3/25 vs Cleveland Guardians W 1-0 F/10
7/2/25 vs Cleveland Guardians W 5-4
7/1/25 vs Cleveland Guardians W 5-2
6/29/25 @ Houston Astros L 2-0

St. Louis Cardinals recent games

Game Date Opponent Result Score
7/4/25 @ Chicago Cubs L 11-3
7/2/25 @ Pittsburgh Pirates L 5-0
7/1/25 @ Pittsburgh Pirates L 1-0
6/30/25 @ Pittsburgh Pirates L 7-0
6/29/25 @ Cleveland Guardians W 7-0

Chicago Cubs injuries

  • Brandon Birdsell (RP): Day-To-Day
  • Eli Morgan (RP): 60-Day-IL
  • Miguel Amaya (C): 10-Day-IL
  • Jameson Taillon (SP): 15-Day-IL
  • Javier Assad (SP): 60-Day-IL

St. Louis Cardinals injuries

  • Jordan Walker (RF): 10-Day-IL
  • Ivan Herrera (C): 10-Day-IL
  • Zack Thompson (RP): 60-Day-IL
  • Drew Rom (SP): Day-To-Day
  • Packy Naughton (RP): Day-To-Day

Cardinals vs Cubs game info

Type Info
Venue Wrigley Field
Location Chicago, Illinois
First pitch Sat 2:20 PM
Temperature 88°
Chance of Rain 1%

Cardinals vs Cubs predictions

All eyes are on the St. Louis Cardinals after that electric 3-homer performance by Michael Busch. For this next matchup at Wrigley, you can bet the spotlight will shine on guys like Nolan Arenado and Willson Contreras, both of whom have been steady anchors in the lineup. Arenado’s ability to find gaps and his knack for knocking in runners means he’ll have plenty of RBI opportunities, while Contreras looks poised for a multi-hit night and could easily tack on a homer, especially given his recent power surge. Brendan Donovan, always underrated, is shaping up for a solid game too; expect him to set the plate with a couple hits and keep the pressure on Chicago’s defense. And don’t sleep on young Nolan Gorman—he might just sneak one over the wall if the wind’s right at Wrigley.

Switching over to the Chicago Cubs, it just feels like Seiya Suzuki’s in the kind of groove where he could do some serious damage again; he’s a constant power threat and his run production has been clutch all season. Nico Hoerner also continues to be a spark plug at the top of the order—picture him notching a pair of hits and maybe swiping a base if the Cardinals get careless. Michael Busch, fresh off a highlight reel game, is probably looking to keep that momentum rolling and you know how Wrigley can reward a hot bat. If the Cubs get guys like Dansby Swanson and Kyle Tucker contributing with consistent contact and timely extra-base hits, St. Louis pitchers could be in for a wild ride. Drew Pomeranz on the mound may not turn heads, but he’s reliable enough to keep the Cubs in it if the offense does their thing early.

When it comes to picking a winner, honestly, you have to lean Chicago here—the combination of home field advantage, one of the best records in MLB at Wrigley, and the way their lineup has been racking up runs just feels tough to bet against. The Cardinals will absolutely make it interesting—those bats are dangerous and Liberatore has shown flashes of brilliance—but at the end of the day, the depth and power in this Chicago Cubs lineup looks a little too much for St. Louis to handle right now. Buckle up, because this rivalry battle is always good for some drama.

Chicago Cubs

St. Louis Cardinals

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