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Seattle Mariners vs. Houston Astros: Preview, Predictions and Picks for May 22, 2025

Updated on:
May 23, 2025 5:00 AM
The Seattle Mariners, currently sitting atop the AL West with a 28-20 record, are set to take on the second-place Houston Astros in the first game of a four-game series on Thursday, May 22, 2025, at Daikin Park. The Astros will look to capitalize on their strong 15-9 home performance, while the Mariners aim to build on their identical 15-9 road record.
Seattle Mariners vs Houston Astros

Current Odds

SEA
HOU
Over
8.5
-107
Under
8.5
+105
SEA
-1.5
+165
HOU
-1.5
+170
SEA
ML
+111
HOU
ML
-117

Mariners vs Astros statistics

Stat Mariners Astros
Hits 382 (22nd) 399 (17th)
Batting Average .236 (22nd) .246 (15th)
Runs Batted In 219 (11th) 186 (21st)
Runs 227 (11th) 195 (22nd)
Home Runs 66 (6th) 45 (Tied-20th)
Walks 191 (Tied-2nd) 154 (Tied-16th)
Stolen Bases 47 (8th) 24 (Tied-27th)
Strikeouts 423 (Tied-20th) 383 (10th)
Pitches 7423 (11th) 6888 (25th)

Houston Astros recent games

Game Date Opponent Result Score
5/21/25 @ Tampa Bay Rays L 8-4
5/20/25 @ Tampa Bay Rays L 3-2
5/19/25 @ Tampa Bay Rays W 4-3
5/18/25 @ Texas Rangers W 4-3
5/17/25 @ Texas Rangers L 5-1

Seattle Mariners recent games

Game Date Opponent Result Score
5/21/25 @ Chicago White Sox W 6-5
5/20/25 @ Chicago White Sox L 1-0
5/19/25 @ Chicago White Sox W 5-1
5/18/25 @ San Diego Padres W 6-1
5/17/25 @ San Diego Padres W 4-1

Houston Astros injuries

  • Yordan Alvarez (LF): 10-Day-IL
  • Brice Matthews (SS): Day-To-Day
  • Ray Gaither (SP): Day-To-Day
  • Jose Fleury (SP): Day-To-Day
  • Ronel Blanco (SP): Day-To-Day

Seattle Mariners injuries

  • George Kirby (SP): 15-Day-IL
  • Taylor Dollard (SP): Day-To-Day
  • Trent Thornton (RP): 15-Day-IL
  • Bryce Miller (SP): 15-Day-IL
  • Logan Gilbert (SP): 15-Day-IL

Mariners vs Astros game info

Type Info
Venue Daikin Park
Location Houston, Texas
First pitch Thu 8:10 PM
Temperature 87°
Chance of Rain 0%

Mariners vs Astros predictions

Seattle Mariners fans have plenty to look forward to as their team rolls into Daikin Park to kick off this four-game series. Keep your eyes on J.P. Crawford, who’s been the Mariners’ most consistent bat so far — it wouldn’t be surprising to see him notch another multi-hit night and draw a walk or two, setting the table for the heart of Seattle’s lineup. Cal Raleigh, swinging for the fences with 16 bombs already, could easily add another big fly if Astros pitching leaves anything over the plate. With Julio Rodriguez heating up as well and always a threat to swipe a bag, the top of the Mariners’ order has the speed and power combo to cause headaches. And speaking of headaches, George Kirby should have Astros hitters in knots if he sticks to his latest form, likely pitching deep into the game while racking up strikeouts and keeping walks to a minimum.

Looking across the diamond, the Houston Astros are quietly building momentum of their own. Jake Meyers has been a machine in center, and he’s primed to pile up hits again tonight, especially with his eye-popping .306 batting average. Isaac Paredes, holding down third, just has that clutch gene — he could easily go deep or drive in a couple runs, adding to his team-leading RBI tally. Jose Altuve and Jeremy Pena round out a lineup that feels overdue for a breakout, and with their ability to make contact and pick up timely RBIs, a big inning always feels just a swing away. On the mound, Lance McCullers Jr. can be dominant when he’s on, and if he can keep the walk totals in check, he’s got the stuff to rack up strikeouts while limiting damage from the Mariners’ big bats.

So, who takes the all-important opener? Both teams have strong narratives, but this feels like the kind of matchup where Houston digs deep, rides home-field energy, and edges out the Mariners in a tight contest. Daikin Park has been good to the Astros, and with their dangerous lineup starting to click and McCullers capable of rising to the moment, don’t be shocked if Houston pulls off a close win to kick off this series. What’s your take — will the Mariners’ road magic continue, or does Houston hold serve at home?

Houston Astros

Seattle Mariners

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