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Cleveland Guardians vs. Detroit Tigers: Preview, Predictions and Picks for May 22, 2025

Updated on:
May 23, 2025 1:36 AM
The Detroit Tigers, riding a three-game home win streak, welcome the Cleveland Guardians to Comerica Park on Thursday, May 22 at 6:40 PM. The Tigers, holding a strong 17-5 home record, look to extend their lead in the AL Central against the fourth-place Guardians, who are 12-14 on the road. This crucial division matchup promises to be an exciting contest between two top AL Central teams.
Cleveland Guardians vs Detroit Tigers

Current Odds

CLE
DET
Over
8.5
-103
Under
8.5
+100
CLE
+1.5
-160
DET
-1.5
+158
CLE
ML
+119
DET
ML
-122

Guardians vs Tigers statistics

Stat Guardians Tigers
Hits 365 (26th) 440 (6th)
Batting Average .234 (23rd) .259 (6th)
Runs Batted In 181 (Tied-23rd) 255 (4th)
Runs 192 (24th) 267 (4th)
Home Runs 53 (Tied-12th) 62 (Tied-8th)
Walks 154 (Tied-16th) 169 (13th)
Stolen Bases 36 (Tied-16th) 20 (30th)
Strikeouts 374 (5th) 435 (26th)
Pitches 6944 (23rd) 7434 (Tied-7th)

Detroit Tigers recent games

Game Date Opponent Result Score
5/21/25 @ St. Louis Cardinals W 5-1
5/20/25 @ St. Louis Cardinals W 5-4
5/19/25 @ St. Louis Cardinals L 11-4
5/18/25 @ Toronto Blue Jays W 3-2
5/17/25 @ Toronto Blue Jays L 2-1

Cleveland Guardians recent games

Game Date Opponent Result Score
5/21/25 @ Minnesota Twins W 5-1
5/19/25 @ Minnesota Twins L 6-5
5/18/25 @ Cincinnati Reds L 3-1
5/17/25 @ Cincinnati Reds L 4-1
5/16/25 @ Cincinnati Reds L 5-4

Detroit Tigers injuries

  • Matt Vierling (CF): 10-Day-IL
  • Casey Mize (SP): 15-Day-IL
  • Wenceel Perez (RF): 60-Day-IL
  • Ty Madden (SP): 60-Day-IL
  • Alex Lange (RP): 60-Day-IL

Cleveland Guardians injuries

  • Chase DeLauter (RF): Day-To-Day
  • Lane Thomas (CF): 10-Day-IL
  • Micah Pries (1B): Day-To-Day
  • David Fry (1B): 60-Day-IL
  • Erik Sabrowski (RP): 60-Day-IL

Guardians vs Tigers game info

Type Info
Venue Comerica Park
Location Detroit, Michigan
First pitch Thu 6:40 PM
Temperature 53°
Chance of Rain 43%

Guardians vs Tigers predictions

Let’s talk Guardians – specifically, the guys who could make some noise at Comerica. Steven Kwan’s been leading the way in the batting average department this season, and it’s hard not to expect another multi-hit game from him. I’m looking for Kwan to get on base at least a couple of times and maybe spark a run or two at the top of the lineup. Over at first, Kyle Manzardo has popped 10 home runs already, so he’s definitely got the pop to go yard if Flaherty hangs one up. Jose Ramirez – the heartbeat of the Guardians infield – is always a threat to drive in runs. If the Tigers’ starter slips, Ramirez is the guy you want at the plate, and I could easily see him knocking in a couple tonight. On the mound, Tanner Bibee feels poised for around five solid innings with steady strikeout stuff, even if Detroit's bats have been hot.

Looking at the Tigers, the home team isn’t just riding a win streak—they’re flat-out rolling, especially at Comerica where they’ve been almost impossible to beat. Riley Greene is really catching fire lately and I’d bet he adds a couple more hits, maybe even goes deep if he gets a good look. The real run producer has been Spencer Torkelson. With 39 RBIs and a knack for clutch knocks, he’s going to be a big problem for the Guardians’ pitching staff. And don’t sleep on Jack Flaherty, who feels like he’s locked in. Expect him to hit five or six innings, keeping the Tigers right in it before the bullpen takes over. If Kerry Carpenter stays patient and pokes one the other way, Detroit’s going to have this lineup firing on all cylinders.

When it’s all said and done, the edge has to go to the Tigers here. They’ve played lights out at home, scoring runs in bunches, and just seem to have an answer for any situation lately. The Guardians can keep it interesting—especially if their top guys find ways to reach base and drive the ball—but Detroit’s combination of power, clutch hitting, and Jack Flaherty’s recent form give them the upper hand. Fans in Detroit have every reason to believe that win streak at Comerica is about to hit four. What do you think—are the Tigers just too tough to topple at home right now?

Detroit Tigers

Cleveland Guardians

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