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San Diego Padres vs. Toronto Blue Jays: Preview, Predictions and Picks for May 22, 2025

Updated on:
May 22, 2025 3:26 PM
The San Diego Padres, seeking to snap a losing skid, travel to Rogers Centre to take on the Toronto Blue Jays on Thursday, May 22, 2025, at 1:07 PM. The Padres, currently third in the NL West, will aim to even the regular season series against the Blue Jays, who hold a 2-0 advantage. In this MLB matchup, San Diego will look to improve their 11-12 road mark against Toronto's 15-12 home record.
San Diego Padres vs Toronto Blue Jays

Current Odds

SD
TOR
Over
12.5
-160
Under
12.5
+150
SD
-1.5
+350
TOR
+1.5
-325
SD
ML
-209
TOR
ML
+220

Padres vs Blue Jays statistics

Stat Padres Blue Jays
Hits 401 (Tied-15th) 402 (14th)
Batting Average .257 (7th) .250 (11th)
Runs Batted In 181 (Tied-23rd) 189 (Tied-19th)
Runs 199 (18th) 196 (21st)
Home Runs 41 (Tied-26th) 44 (Tied-23rd)
Walks 145 (Tied-23rd) 152 (18th)
Stolen Bases 36 (Tied-16th) 31 (Tied-20th)
Strikeouts 326 (1st) 357 (3rd)
Pitches 6594 (30th) 6905 (24th)

Toronto Blue Jays recent games

Game Date Opponent Result Score
5/21/25 vs San Diego Padres W 14-0
5/20/25 vs San Diego Padres W 3-0
5/18/25 vs Detroit Tigers L 3-2
5/17/25 vs Detroit Tigers W 2-1
5/16/25 vs Detroit Tigers L 5-4

San Diego Padres recent games

Game Date Opponent Result Score
5/21/25 @ Toronto Blue Jays L 14-0
5/20/25 @ Toronto Blue Jays L 3-0
5/18/25 vs Seattle Mariners L 6-1
5/17/25 vs Seattle Mariners L 4-1
5/16/25 vs Seattle Mariners L 5-1

Toronto Blue Jays injuries

  • Anthony Santander (RF): Day-To-Day
  • Nick Sandlin (RP): 15-Day-IL
  • Ryan Burr (RP): 60-Day-IL
  • Erik Swanson (RP): 60-Day-IL
  • Hayden Juenger (SP): Day-To-Day

San Diego Padres injuries

  • Logan Gillaspie (RP): 15-Day-IL
  • Mason McCoy (2B): 10-Day-IL
  • Yu Darvish (SP): 15-Day-IL
  • Bryan Hoeing (RP): 60-Day-IL
  • Matt Waldron (SP): 60-Day-IL

Padres vs Blue Jays game info

Type Info
Venue Rogers Centre
Location Toronto, Ontario
First pitch Thu 1:07 PM

Padres vs Blue Jays predictions

When you look at the San Diego Padres lineup, it’s hard not to get excited about what Manny Machado and Fernando Tatis Jr. can do against the Blue Jays. Machado is looking locked in right now—expect him to tack on another multi-hit game, with a good shot at an extra-base hit or even sending one out of Rogers Centre. Tatis Jr. just has a knack for showing up in big moments and I wouldn’t be surprised if he leaves his mark with a couple of RBIs and a solo homer. And don’t overlook Luis Arraez—his ability to rack up singles at the top of the order should give the Padres plenty of chances to drive in runs and set the tone early. On the mound, Stephen Kolek seems poised for a solid showing, likely holding Toronto to just a couple of runs across the first five innings and collecting a handful of strikeouts along the way.

Shifting attention to the Toronto Blue Jays, Bo Bichette is the engine that keeps their offense humming. He’s been hitting for average all season, so expect another productive night at the plate with at least one or two base hits—maybe even an RBI to keep things close. Vladimir Guerrero Jr. has the kind of power that can flip the game with one swing, and you can usually count on him contributing both at bat and in the field. Meanwhile, Daulton Varsho always has the potential to surprise with a clutch homer or stolen base, which could swing momentum if things get tight late. On the pitching side, Bowden Francis is coming into this one looking fairly sharp. If he can keep the ball in the park and limit the walks, he may be able to give his team a chance by keeping the Padres’ key bats at bay for five or six frames.

Picking a winner in this matchup isn’t easy, especially with the Padres hungry to snap their skid and the Blue Jays playing solid ball at home. But given San Diego’s slightly deeper lineup and the way their stars are trending, there’s a good feeling that the Padres will find a way to grind out a win at Rogers Centre. It could come down to one or two big swings, but with Tatis Jr. and Machado heating up, San Diego just feels a little more dangerous in those clutch spots tonight. What do you think—is this the night the Padres flip the script?

Toronto Blue Jays

San Diego Padres

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