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Miami Marlins vs. San Diego Padres: Preview, Predictions and Picks for May 28, 2025

Updated on:
May 28, 2025 5:16 PM
The San Diego Padres, riding high with a 31-22 record, look to sweep the series against the Miami Marlins, who are struggling on the road with an 8-17 record, at Petco Park on Wednesday, May 28, 2025, at 4:10 PM. The Padres have dominated the series so far, leading 2-0 and will aim to capitalize on their strong home form to secure the win.
Miami Marlins vs San Diego Padres

Current Odds

MIA
SD
Over
15.5
+140
Under
16.5
+105
MIA
-1.5
+250
SD
-1.5
+325
MIA
ML
+475
SD
ML
+145

Marlins vs Padres statistics

Stat Marlins Padres
Hits 453 (13th) 448 (15th)
Batting Average .250 (12th) .253 (9th)
Runs Batted In 210 (19th) 205 (22nd)
Runs 219 (20th) 225 (Tied-16th)
Home Runs 48 (24th) 51 (Tied-20th)
Walks 164 (Tied-20th) 164 (Tied-20th)
Stolen Bases 46 (Tied-12th) 39 (Tied-16th)
Strikeouts 441 (13th) 376 (1st)
Pitches 7546 (29th) 7497 (30th)

San Diego Padres recent games

Game Date Opponent Result Score
5/27/25 vs Miami Marlins W 8-6
5/26/25 vs Miami Marlins W 4-3 F/11
5/25/25 @ Atlanta Braves W 5-3
5/24/25 @ Atlanta Braves L 7-1
5/23/25 @ Atlanta Braves W 2-1

Miami Marlins recent games

Game Date Opponent Result Score
5/27/25 @ San Diego Padres L 8-6
5/26/25 @ San Diego Padres L 4-3 F/11
5/25/25 @ Los Angeles Angels W 3-0
5/24/25 @ Los Angeles Angels W 6-2
5/23/25 @ Los Angeles Angels L 7-4

San Diego Padres injuries

  • Mason McCoy (2B): 10-Day-IL
  • Bryan Hoeing (RP): 60-Day-IL
  • Matt Waldron (SP): 60-Day-IL
  • Jason Heyward (LF): 10-Day-IL
  • Logan Gillaspie (RP): 15-Day-IL

Miami Marlins injuries

  • Woo-Suk Go (RP): Day-To-Day
  • Xavier Edwards (SS): 10-Day-IL
  • Declan Cronin (RP): 15-Day-IL
  • Dane Myers (CF): 10-Day-IL
  • Andrew Nardi (RP): 60-Day-IL

Marlins vs Padres game info

Type Info
Venue Petco Park
Location San Diego, California
First pitch Wed 4:10 PM
Temperature 68°
Chance of Rain 0%

Marlins vs Padres predictions

Looking at the Miami Marlins heading into this matchup, it’s clear they’ll be counting on some big swings from Kyle Stowers at Petco Park. Stowers has quietly pieced together a strong season so far, and I like his chances to put together another multi-hit effort—possibly even sneaking one over the wall the way he’s been swinging the bat. Otto Lopez should find himself right in the middle of the action too, likely getting on base a couple of times and creating some opportunities for the Marlins to string together runs. With Sandy Alcantara taking the mound, you can expect him to keep the Padres guessing for at least five to six innings—he’s usually pretty solid at limiting damage, although a couple of runs here and there is probably inevitable against this Padres offense.

On the San Diego side, Manny Machado looks locked in at the plate—don’t be surprised if he racks up a few base knocks and maybe even drives in a run or two. Fernando Tatis Jr. is another guy who always seems to show up in the big moments, and the way he’s been seeing the ball lately, you might just see him do it all: get on base, swipe a bag, and send one into the seats. With Kyle Hart starting for the Padres, I see him keeping things pretty steady through the middle innings, relying on his ability to pick up strikeouts and limit the Marlins’ heavy hitters. Add in some potential RBI production from Gavin Sheets, and the Padres’ offense has plenty of ways to scratch across runs.

So, who comes out on top? With the momentum San Diego has at home and an offense that knows how to produce in the clutch, I think the Padres have the edge to secure the sweep. The Marlins have players who can make noise, but the depth and consistency throughout the Padres’ lineup—and the advantage of their home crowd—make them tough to beat in this spot. Don’t be surprised if San Diego closes out the series strong and keeps their spot near the top of the NL West.

San Diego Padres

Miami Marlins

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