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Kansas City Chiefs vs. Los Angeles Chargers: Preview, Predictions and Picks for September 5, 2025

Updated on:
Jul 14, 2025 11:37 PM
Get ready for a thrilling AFC West showdown as the Kansas City Chiefs take on the Los Angeles Chargers on Friday, September 5, 2025, at 8:00 PM! The high-powered Chiefs offense, led by Patrick Mahomes, looks to exploit the Chargers' vulnerable secondary, while Justin Herbert and company aim to capitalize on their own explosive playmaking abilities. Expect a fast-paced, high-scoring affair in this crucial divisional matchup.
Kansas City Chiefs vs Los Angeles Chargers

Current Odds

KC
LAC
Over
45.5
-105
Under
44.5
+108
KC
-2.5
-110
LAC
+2.5
+100
KC
ML
-140
LAC
ML
+130

Los Angeles Chargers recent games

Game Date Opponent Result Score
1/11/25 @ Houston Texans L 32-12
1/5/25 @ Las Vegas Raiders W 34-20
12/28/24 @ New England Patriots W 40-7
12/19/24 vs Denver Broncos W 34-27
12/15/24 vs Tampa Bay Buccaneers L 40-17

Kansas City Chiefs recent games

Game Date Opponent Result Score
2/9/25 vs Philadelphia Eagles L 40-22
1/26/25 vs Buffalo Bills W 32-29
1/18/25 vs Houston Texans W 23-14
1/5/25 @ Denver Broncos L 38-0
12/25/24 @ Pittsburgh Steelers W 29-10

Los Angeles Chargers injuries

  • Najee Harris (RB): Questionable
  • Cam Hart (CB): Questionable
  • Mike Williams (WR): Questionable
  • Elijah Molden (CB): Questionable
  • Ja'Sir Taylor (CB): Questionable

Kansas City Chiefs injuries

  • Josh Simmons (OT): Questionable
  • Jared Wiley (TE): Questionable
  • Keaontay Ingram (RB): Injured Reserve
  • BJ Thompson (DE): Out

Chiefs vs Chargers game info

Type Info
Venue Corinthians Arena
Location Sao Paulo
Kickoff Fri 8:00 PM

Chiefs vs Chargers predictions

Let’s talk about the Kansas City Chiefs first—because you know the spotlight always seems to shine a little brighter on them, especially with Patrick Mahomes under center. I’m expecting another classic Mahomes performance, with somewhere in the mid-250s for passing yards, around two touchdowns, and those occasional dazzling throws only he can make. Isiah Pacheco should get a solid workload, pushing up close to 50 rushing yards and possibly finding the end zone, while the receiving group is set to offer plenty of targets for Rashee Rice and Xavier Worthy—both hovering around the 50-yard mark and capable of breaking things open if the Chargers’ defense slips up. And let’s not forget Travis Kelce, who should have his usual impact, hauling in over 40 yards and staying a reliable red zone threat.

Now, flipping over to the Chargers, the offense will lean heavily on Justin Herbert’s arm—and I see him tossing for about 215 yards with a couple of touchdowns, flinging darts to a dynamic receiving corps highlighted by Ladd McConkey, who could easily lead the team with 60-plus yards and a trip to the end zone. The backfield looks like a pretty even split, with Omarion Hampton churning out solid gains and maybe finding pay dirt, while Najee Harris chips in as a complementary option. Tre Harris and Quentin Johnston both have the potential to be sneaky options through the air, each with the ability to stretch the field or make a big-play difference at just the right moment.

With everything on the table—and factoring in the electric São Paulo atmosphere—my gut says this tilt will be tight, but Kansas City just has too much magic when it matters. Mahomes and his crew tend to rise to these showcase spots, and the rest of the Chiefs’ playmakers seem primed to do just enough to edge out Herbert’s Chargers. I’m backing the Chiefs to find a way to win late, covering that narrow 2.5-point spread and sending their fans home happy from Brazil. What do you think—are you putting your faith in Mahomes, or do you see the Chargers springing an upset?

Los Angeles Chargers

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