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Houston Astros vs. Chicago White Sox: Preview, Predictions and Picks for May 4, 2025

Updated on:
May 4, 2025 5:04 PM
On Sunday, May 4th at 2:10 PM, the Houston Astros, fresh off a strong performance, will face the Chicago White Sox at Guaranteed Rate Field. The Astros, led by Meyers after his impressive 4-hit display, look to take the lead in the series against the struggling Sox, who are currently 9-24 overall and 6-11 at home.
Houston Astros vs Chicago White Sox

Current Odds

HOU
CHW
Over
11.0
-117
Under
10.5
+135
HOU
+1.5
-300
CHW
-1.5
+225
HOU
ML
+260
CHW
ML
-335

Astros vs White Sox statistics

Stat Astros White Sox
Hits 256 (22nd) 230 (28th)
Batting Average .241 (16th) .215 (29th)
Runs Batted In 121 (19th) 116 (23rd)
Runs 128 (Tied-19th) 119 (24th)
Home Runs 28 (Tied-21st) 26 (27th)
Walks 101 (Tied-21st) 115 (15th)
Stolen Bases 21 (Tied-21st) 23 (Tied-17th)
Strikeouts 259 (9th) 282 (21st)
Pitches 4575 (26th) 4695 (22nd)

Chicago White Sox recent games

Game Date Opponent Result Score
5/3/25 vs Houston Astros L 8-3
5/2/25 vs Houston Astros W 7-3
5/1/25 vs Milwaukee Brewers W 8-0
4/30/25 vs Milwaukee Brewers L 6-4
4/29/25 vs Milwaukee Brewers L 7-2

Houston Astros recent games

Game Date Opponent Result Score
5/3/25 @ Chicago White Sox W 8-3
5/2/25 @ Chicago White Sox L 7-3
4/30/25 vs Detroit Tigers L 7-4
4/29/25 vs Detroit Tigers W 6-4
4/28/25 vs Detroit Tigers W 8-5

Chicago White Sox injuries

  • Korey Lee (C): 10-Day-IL
  • Josh Rojas (3B): 10-Day-IL
  • Mike Tauchman (RF): 10-Day-IL
  • Gage Workman (3B): 10-Day-IL
  • Brandon Drury (2B): Out

Houston Astros injuries

  • Yordan Alvarez (LF): Day-To-Day
  • Lance McCullers Jr. (SP): 15-Day-IL
  • Shawn Dubin (RP): 15-Day-IL
  • Pedro Leon (RF): 10-Day-IL
  • Ray Gaither (SP): Day-To-Day

Astros vs White Sox game info

Type Info
Venue Rate Field
Location Chicago, Illinois
First pitch Sun 2:10 PM
Temperature 51°
Chance of Rain 11%

Astros vs White Sox predictions

The Houston Astros come into the game with some intriguing player projections that could tip the scales in their favor. José Altuve is expected to have a decent outing, potentially securing multiple hits in his four at-bats. You can always count on Yordan Alvarez to make an impact, despite his day-to-day status due to a pesky hand inflammation. One can anticipate Altuve and Alvarez working their magic on the field as they try to capitalize on Chicago's pitching. Meanwhile, keep an eye on Jake Meyers, who had an impressive four-hit performance recently and could continue that momentum. With Lance McCullers Jr. likely taking the mound, there’s a strong sense he will be anchoring the team’s defense, aiming to keep those White Sox bats in check.

Switching gears to the Chicago White Sox, they’ll be looking to claw an edge with Bryse Wilson stepping in as the starting pitcher. His balance of skill and strategy will be a key component of their game plan. Though the White Sox have been struggling, players like Lenyn Sosa, with his relatively solid batting average, will look to make a statement at the plate. Then there's Andrew Benintendi, who looks poised to add some fireworks of his own with his team-leading home runs. In the field, Luis Robert Jr. will want to step up and contribute significantly in the RBI department. If the White Sox can align these individual performances, they might just mount a spirited challenge.

When it comes to picking a winner for this MLB showdown, the Houston Astros seem to have the upper hand, on paper at least. Their current record edges past the White Sox, and the sheer depth of their lineup offers the potential for a decisive offensive display. The White Sox, while having home-field advantage, have a significant hill to climb against an Astros team whose recent form suggests they’re finding their groove. But baseball can be an unpredictable game, and if the White Sox can harness some early momentum, there’s always the potential for an upset. In a close match-up, my bet would lean toward the Astros securing victory thanks to their combination of strategic pitching and dynamic offensive capabilities. What do you think? Could be an exciting game to watch!

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