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Cleveland Guardians vs. Minnesota Twins: Preview, Predictions and Picks for May 21, 2025

Updated on:
May 21, 2025 12:30 PM
On Wednesday, May 21, 2025, at 3:00 PM, the Minnesota Twins will host the Cleveland Guardians at Target Field. The Twins, with a strong home record of 15-6, will look to gain ground on the Guardians, who currently lead the regular season series 1.
Cleveland Guardians vs Minnesota Twins

Current Odds

CLE
MIN
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Under
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CLE
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MIN
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CLE
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Guardians vs Twins statistics

Stat Guardians Twins
Hits 346 (27th) 380 (21st)
Batting Average .233 (23rd) .242 (17th)
Runs Batted In 171 (24th) 185 (19th)
Runs 182 (Tied-23rd) 194 (19th)
Home Runs 51 (Tied-13th) 45 (Tied-20th)
Walks 149 (Tied-17th) 132 (Tied-26th)
Stolen Bases 36 (Tied-15th) 26 (Tied-23rd)
Strikeouts 360 (4th) 385 (11th)
Pitches 6634 (27th) 6893 (19th)

Minnesota Twins recent games

Game Date Opponent Result Score
5/18/25 @ Milwaukee Brewers L 5-2
5/17/25 @ Milwaukee Brewers W 7-0
5/16/25 @ Milwaukee Brewers W 3-0
5/15/25 @ Baltimore Orioles W 4-0
5/14/25 @ Baltimore Orioles W 8-6

Cleveland Guardians recent games

Game Date Opponent Result Score
5/18/25 @ Cincinnati Reds L 3-1
5/17/25 @ Cincinnati Reds L 4-1
5/16/25 @ Cincinnati Reds L 5-4
5/14/25 vs Milwaukee Brewers L 9-5
5/13/25 vs Milwaukee Brewers W 2-0

Minnesota Twins injuries

  • Byron Buxton (CF): 7-day il
  • Carlos Correa (SS): 7-Day IL
  • Yunior Severino (1B): Day-To-Day
  • Matt Wallner (RF): 10-Day-IL
  • Erasmo Ramirez (RP): Day-To-Day

Cleveland Guardians injuries

  • Lane Thomas (CF): 10-Day-IL
  • Chase DeLauter (RF): Day-To-Day
  • Micah Pries (1B): Day-To-Day
  • David Fry (1B): 60-Day-IL
  • Erik Sabrowski (RP): 60-Day-IL

Guardians vs Twins game info

Type Info
Venue Target Field
Location Minneapolis, Minnesota
First pitch Wed 3:00 PM
Temperature 49°
Chance of Rain 67%

Guardians vs Twins predictions

Looking at the Guardians going into this one, there’s a lot riding on Steven Kwan at the top of the lineup. He’s been swinging one of the hotter bats with a team-leading .311 average, so it’s not much of a stretch to see him collecting a couple of hits and maybe snagging a run or two if things click early. Power-wise, Kyle Manzardo is the big bopper to watch. With 10 home runs and 25 RBIs already, it wouldn’t be a shocker to see him tag one over the fence at Target Field, especially since the Guardians need everything they can get in the race for runs. Now, Gavin Williams has the ball for Cleveland, and the Twins aren’t exactly raking at the plate this season, so if Williams can limit hard contact and keep the ball in the yard, he could give the Guardians a real fighting chance.

Minnesota, meanwhile, is looking for someone to step up with Byron Buxton working back from a concussion. His absence is definitely a blow since he leads them in average, homers, and RBIs—basically, there’s a Buxton-shaped hole in the lineup that just doesn’t go away. Guys like Carlos Correa and Edouard Julien are left to shoulder the burden; you can imagine Correa coming through for a couple of knocks tonight, maybe with a timely double in the gap. On the mound, Chris Paddack has been solid at home, and facing a Guardians lineup that isn’t exactly overflowing with hits or high on-base guys, he’s got a legit shot at putting together a quality start—think six innings, a handful of strikeouts, not too many fireworks.

When it comes down to picking a winner, this matchup feels close, but the Twins’ home record kind of jumps off the page. Even without Buxton, Minnesota just seems to find a way to grind out wins at Target Field, especially with Paddack on the bump and a bullpen that usually keeps things cool late. The Guardians are tough, and if their stars can break out, it’ll be a real fight—but in this one, I’m leaning Minnesota by a nose. What’s your gut say?

Minnesota Twins

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Cleveland Guardians

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