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San Diego Padres vs. San Francisco Giants: Preview, Predictions and Picks for June 5, 2025

Updated on:
Jun 5, 2025 4:55 PM
The San Diego Padres look to extend their series lead against the San Francisco Giants on Thursday at Oracle Park. With a 2-1 series advantage, the Padres aim to capitalize on their 35-25 overall record, including a 15-15 road record, to take another win from their NL West rivals. First pitch is set for 3:45 PM on June 5, 2025.
San Diego Padres vs San Francisco Giants

Current Odds

SD
SF
Over
5.5
-115
Under
6.5
-110
SD
+1.5
-455
SF
-1.5
+375
SD
ML
+395
SF
ML
-278

Padres vs Giants statistics

Stat Padres Giants
Hits 498 (18th) 473 (24th)
Batting Average .249 (12th) .231 (25th)
Runs Batted In 231 (Tied-20th) 245 (18th)
Runs 251 (20th) 256 (17th)
Home Runs 53 (Tied-25th) 59 (22nd)
Walks 186 (Tied-20th) 215 (11th)
Stolen Bases 46 (16th) 37 (21st)
Strikeouts 415 (1st) 521 (21st)
Pitches 8453 (28th) 9129 (12th)

San Francisco Giants recent games

Game Date Opponent Result Score
6/4/25 vs San Diego Padres W 6-5
6/3/25 vs San Diego Padres L 3-2 F/10
6/2/25 vs San Diego Padres L 1-0 F/10
6/1/25 @ Miami Marlins W 4-2
5/31/25 @ Miami Marlins L 1-0

San Diego Padres recent games

Game Date Opponent Result Score
6/4/25 @ San Francisco Giants L 6-5
6/3/25 @ San Francisco Giants W 3-2 F/10
6/2/25 @ San Francisco Giants W 1-0 F/10
6/1/25 vs Pittsburgh Pirates W 6-4
5/31/25 vs Pittsburgh Pirates L 5-0

San Francisco Giants injuries

  • Helcris Olivarez (SP): Day-To-Day
  • Cole Waites (RP): Day-To-Day
  • Justin Verlander (SP): 15-Day-IL
  • Kyle Harrison (RP): Day-To-Day
  • Ethan Small (SP): Day-To-Day

San Diego Padres injuries

  • Xander Bogaerts (SS): Day-To-Day
  • Bryan Hoeing (RP): 60-Day-IL
  • Jason Heyward (LF): 10-Day-IL
  • Mason McCoy (2B): 10-Day-IL
  • Logan Gillaspie (RP): 15-Day-IL

Padres vs Giants game info

Type Info
Venue Oracle Park
Location San Francisco, California
First pitch Thu 3:45 PM
Temperature 56°
Chance of Rain 0%

Padres vs Giants predictions

With the Padres coming into Oracle Park leading the series 2-1, all eyes are on their big bats and pitching staff to keep the momentum rolling. Manny Machado is looking locked in lately, and I wouldn’t be surprised to see him grab a couple of hits, maybe even go yard if he gets a good look at a fastball. Fernando Tatis Jr. is another guy to watch—he’s showing off his all-around game, which makes him a threat every time he steps to the plate; expect him to find his way on base and maybe swipe a bag. On the mound, Dylan Cease has that swing-and-miss stuff that could be a headache for the Giants’ lineup, and if he brings his A-game, he’s got six or more strikeouts just waiting in his back pocket.

Speaking of the Giants, they’re not just going to roll over at home with the series on the line. Heliot Ramos has been steady as anything in left field, and with his bat heating up, it feels like he’s due for multiple hits and possibly a clutch RBI. Matt Chapman’s power can flip a game in a blink, so if Cease isn’t careful, Chapman could really make him pay. Robbie Ray gets the nod on the bump for San Francisco, and while he’ll have to work carefully around the Padres’ toughest bats, he’s got the kind of stuff to rack up some strikeouts and keep things tight through the middle innings.

So, how’s this game shaping up? It’s going to be a close one—a classic NL West grind. The Padres have been tough on the road and are carrying that slight edge from the series lead, but with the Giants at Oracle Park and Robbie Ray on the hill, this could be the night San Francisco claws one back. I’m leaning just a bit toward the Giants taking this one, using that home field energy and a spark from the middle of their order. Wouldn’t you love to see a rubber match?

San Francisco Giants

San Diego Padres

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