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Houston Astros vs. Los Angeles Angels: Preview, Predictions and Picks for June 22, 2025

Updated on:
Jun 22, 2025 5:37 PM
On Sunday, June 22, 2025, at 4:07 PM, the Houston Astros (44-33, first in the AL West) face off against the Los Angeles Angels (37-39, fourth in the AL West) in the rubber match of their series at Angel Stadium. The Astros, led by their strong overall record, look to take the series win, while the Angels aim to bounce back on their home turf. The matchup promises to be an exciting one as these two AL West rivals clash.
Houston Astros vs Los Angeles Angels

Current Odds

HOU
LAA
Over
14.5
+260
Under
14.5
-196
HOU
-2.5
+400
LAA
+1.5
+550
HOU
ML
-2500
LAA
ML
+1438

Astros vs Angels statistics

Stat Astros Angels
Hits 661 (Tied-9th) 570 (28th)
Batting Average .256 (6th) .225 (28th)
Runs Batted In 310 (16th) 303 (Tied-20th)
Runs 325 (16th) 314 (22nd)
Home Runs 81 (Tied-15th) 110 (Tied-3rd)
Walks 225 (Tied-23rd) 192 (29th)
Stolen Bases 43 (Tied-21st) 35 (29th)
Strikeouts 599 (Tied-6th) 740 (29th)
Pitches 10758 (26th) 10909 (21st)

Los Angeles Angels recent games

Game Date Opponent Result Score
6/21/25 vs Houston Astros W 9-1
6/20/25 vs Houston Astros L 3-2 F/10
6/19/25 @ New York Yankees L 7-3
6/18/25 @ New York Yankees W 3-2
6/17/25 @ New York Yankees W 4-0

Houston Astros recent games

Game Date Opponent Result Score
6/21/25 @ Los Angeles Angels L 9-1
6/20/25 @ Los Angeles Angels W 3-2 F/10
6/19/25 @ Athletics L 6-4 F/10
6/18/25 @ Athletics W 11-4
6/17/25 @ Athletics W 13-3

Los Angeles Angels injuries

  • Kevin Newman (SS): Day-To-Day
  • Victor Gonzalez (RP): Day-To-Day
  • Yoan Moncada (3B): 10-Day-IL
  • Jorge Soler (RF): 10-Day-IL
  • Angel Felipe (RP): Day-To-Day

Houston Astros injuries

  • Taylor Trammell (LF): 10-Day-IL
  • Blake Weiman (RP): Day-To-Day
  • Glenn Otto (RP): Day-To-Day
  • Brendan Rodgers (2B): 10-Day-IL
  • Pedro Leon (RF): 10-Day-IL

Astros vs Angels game info

Type Info
Venue Angel Stadium
Location Anaheim, California
First pitch Sun 4:07 PM
Temperature 62°
Chance of Rain 0%

Astros vs Angels predictions

All eyes are going to be on the Houston Astros lineup in this series finale, and for good reason. Jeremy Pena is in the middle of a hot streak, and with a batting average north of .320, it wouldn’t shock me if he racks up a couple of hits and maybe even finds his way home twice. Isaac Paredes, one of the most consistent power bats for Houston this year, projects to add another extra-base knock, possibly even send one into the stands, while Altuve’s knack for clutch at-bats could have him reaching base a handful of times—look for at least one run scored, because that’s just classic Altuve. Starting pitcher Ryan Gusto looks solid for about five innings, maybe allowing a run or two, but I’m thinking he’ll be able to rack up close to five strikeouts before the bullpen takes over.

When it comes to the Los Angeles Angels, Taylor Ward has been pacing this offense and you can expect more of the same. He’s got the pop to change the game with one swing, so don’t be surprised if he delivers a home run or drives in a pair. Nolan Schanuel should chip in with a steady performance, maybe a hit or two and get on base at least once. And everyone knows, if Mike Trout is in the lineup, he’s always a threat—expect him to be right in the middle of the action with a couple of hits and maybe even knock one out of the park. On the mound, Kyle Hendricks can eat some innings for the Angels, and I see him keeping Houston honest through at least the fifth, while limiting the damage to a couple of earned runs.

With the Astros having a deeper lineup and a slight edge in pitching—plus holding a winning record in the series—it feels like they’ve got just enough firepower to take this rubber match at Angel Stadium. The Angels will no doubt put up a fight, especially with their heavy hitters in good form, but Houston’s consistency up and down the order might just tip the scale. If you’re looking for a pick, it’s hard to go against the Astros coming out on top in a tight one. What’s your gut telling you—will Houston make it four wins in this series?

Los Angeles Angels

Houston Astros

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