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Houston Astros vs. Cleveland Guardians: Preview, Predictions and Picks for June 6, 2025

Updated on:
Jun 6, 2025 8:40 PM
The Houston Astros, sitting atop the AL West with a 34-28 record, travel to Progressive Field to take on the Cleveland Guardians, who hold a 33-28 record, good for third in the AL Central. The Astros will look to improve their 12-16 road record, while the Guardians will aim to capitalize on their strong 17-11 home record.
Houston Astros vs Cleveland Guardians

Current Odds

HOU
CLE
Over
6.5
+495
Under
6.5
-660
HOU
-2.5
-142
CLE
+1.5
+920
HOU
ML
-3000
CLE
ML
+6600

Astros vs Guardians statistics

Stat Astros Guardians
Hits 519 (12th) 465 (26th)
Batting Average .252 (10th) .234 (24th)
Runs Batted In 239 (21st) 228 (24th)
Runs 250 (Tied-21st) 241 (23rd)
Home Runs 63 (Tied-17th) 63 (Tied-17th)
Walks 176 (25th) 193 (19th)
Stolen Bases 33 (Tied-26th) 47 (Tied-15th)
Strikeouts 476 (6th) 492 (Tied-11th)
Pitches 8625 (26th) 8797 (22nd)

Cleveland Guardians recent games

Game Date Opponent Result Score
6/5/25 @ New York Yankees L 4-0
6/4/25 @ New York Yankees W 4-0
6/3/25 @ New York Yankees L 3-2
6/1/25 vs Los Angeles Angels W 4-2
5/31/25 vs Los Angeles Angels W 7-5

Houston Astros recent games

Game Date Opponent Result Score
6/5/25 @ Pittsburgh Pirates W 8-2
6/4/25 @ Pittsburgh Pirates L 3-0
6/3/25 @ Pittsburgh Pirates W 3-0
6/1/25 vs Tampa Bay Rays W 1-0
5/31/25 vs Tampa Bay Rays L 16-3

Cleveland Guardians injuries

  • Lane Thomas (CF): 10-Day-IL
  • George Valera (RF): Day-To-Day
  • Trevor Stephan (RP): 60-Day-IL
  • Will Brennan (RF): 10-Day-IL
  • Micah Pries (1B): Day-To-Day

Houston Astros injuries

  • Blake Weiman (RP): Day-To-Day
  • Jose Fleury (SP): Day-To-Day
  • Chas McCormick (LF): 10-Day-IL
  • Pedro Leon (RF): 10-Day-IL
  • Taylor Trammell (LF): 10-Day-IL

Astros vs Guardians game info

Type Info
Venue Progressive Field
Location Cleveland, Ohio
First pitch Fri 7:10 PM
Temperature 66°
Chance of Rain 43%

Astros vs Guardians predictions

If you’ve been following the Houston Astros this season, you know they’ve got a lineup loaded with guys who can make things happen on any given night. Keep an eye on Jeremy Pena—he’s been swinging a hot bat lately, and I think he’ll continue to set the tone at the top of the order, picking up a couple of hits and maybe even scoring a run or two. Jose Altuve’s consistency can’t be ignored either; look for him to get on base multiple times and put some pressure on Guardians starter Logan Allen. And don’t be surprised if Isaac Paredes drives in a key RBI, possibly with some extra-base pop to his swings. On the mound, Colton Gordon is lined up for Houston, and if he can keep his walks under control, he should be able to keep Cleveland’s bats quiet for at least five solid innings.

As the Guardians get ready to defend Progressive Field, everyone is naturally watching Jose Ramirez—he’s just relentless in the heart of Cleveland’s order. I expect Ramirez to be right in the thick of the action, likely reaching base a couple times and adding to his already-impressive tally of RBIs and runs scored. Carlos Santana’s veteran bat still packs a punch, so don’t be surprised if he sneaks in an extra-base hit and drives home a run. Steven Kwan, meanwhile, has a knack for putting the ball in play and getting on base; I can see him collecting at least one or two hits and finding a way to cross the plate. With Logan Allen starting, it’ll come down to how well he manages the Astros’ top hitters in those middle innings—if he keeps the long ball at bay, he can give Cleveland a real shot.

Taking everything into account, this matchup feels close, but Progressive Field has been a nice home advantage for the Guardians so far this year. With Allen grinding out competitive innings and Ramirez surrounded by bats that can chip in, I see Cleveland squeezing out a win in a tight one—especially if their bullpen steps up late. But with the firepower on both sides, whoever makes fewer mistakes under pressure will likely come out on top. Should be a fun way to kick off this three-game set! What’s your call—are the Astros going to crash the party, or will the Guardians hold serve at home?

Cleveland Guardians

Houston Astros

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