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St. Louis Cardinals vs. Chicago White Sox: Preview, Predictions and Picks for June 17, 2025

Updated on:
Jun 17, 2025 11:15 AM
The St. Louis Cardinals, currently fourth in the NL Central with a 37-35 record, travel to Guaranteed Rate Field to take on the struggling Chicago White Sox, who sit at the bottom of the AL Central. The Sox will look to turn their season around at home, where they hold a 16-18 record, while the Cardinals aim to improve their 15-21 road record. This MLB matchup is set for Tuesday, June 17, 2025, at 7:40 PM.
St. Louis Cardinals vs Chicago White Sox

Current Odds

STL
CHW
Over
9.0
+100
Under
8.5
+117
STL
-1.5
+122
CHW
+1.0
-102
STL
ML
-133
CHW
ML
+129

Cardinals vs White Sox statistics

Stat Cardinals White Sox
Hits 624 (6th) 523 (30th)
Batting Average .255 (3rd) .222 (30th)
Runs Batted In 312 (11th) 238 (28th)
Runs 328 (Tied-10th) 248 (27th)
Home Runs 66 (23rd) 55 (28th)
Walks 228 (18th) 235 (15th)
Stolen Bases 39 (24th) 51 (Tied-18th)
Strikeouts 562 (8th) 628 (Tied-22nd)
Pitches 10634 (10th) 10333 (20th)

Chicago White Sox recent games

Game Date Opponent Result Score
6/15/25 @ Texas Rangers L 2-1
6/14/25 @ Texas Rangers L 5-4 F/11
6/13/25 @ Texas Rangers L 3-1
6/12/25 @ Houston Astros L 4-3
6/11/25 @ Houston Astros L 10-2

St. Louis Cardinals recent games

Game Date Opponent Result Score
6/15/25 @ Milwaukee Brewers L 3-2
6/14/25 @ Milwaukee Brewers W 8-5
6/13/25 @ Milwaukee Brewers L 3-2
6/12/25 @ Milwaukee Brewers L 6-0
6/11/25 vs Toronto Blue Jays L 5-2

Chicago White Sox injuries

  • Luis Robert Jr. (CF): Day-To-Day
  • Lenyn Sosa (2B): 10-Day-IL
  • Jesse Scholtens (RP): 60-Day-IL
  • Jared Shuster (RP): 15-Day-IL
  • Hagen Smith (SP): Day-To-Day

St. Louis Cardinals injuries

  • Drew Rom (SP): Day-To-Day
  • Zack Thompson (RP): 60-Day-IL
  • Packy Naughton (RP): Day-To-Day
  • Victor Santos (RP): Day-To-Day
  • Cooper Hjerpe (SP): Day-To-Day

Cardinals vs White Sox game info

Type Info
Venue Rate Field
Location Chicago, Illinois
First pitch Tue 7:40 PM
Temperature 87°
Chance of Rain 47%

Cardinals vs White Sox predictions

When it comes to sizing up the St. Louis Cardinals in this matchup, keep an eye on Brendan Donovan—he’s been such a reliable bat lately, and he looks poised to rack up multiple hits against Chicago’s pitching. Willson Contreras shouldn’t be far behind either—he’s got the pop and the patience to drive in runs while working deep into counts. Add Alec Burleson to the list of potential difference-makers, since he’s been consistent at the plate and has shown a knack for getting on base. And let’s not forget about Matthew Liberatore on the mound: he’s set up for a strong outing, with plenty of punchouts and the chance to keep the Sox lineup quiet through the middle innings.

Flipping over to the Chicago White Sox, fans will be looking for something to spark them offensively, and Miguel Vargas could be that guy. He’s shown flashes of power and leads the Sox in both home runs and RBIs, so if anyone’s going to make some noise, it’s him. Luis Robert Jr. brings a dynamism that can change a game in just one at-bat or on the basepaths, and he’s primed for solid contact and a chance to swipe a bag or two. For pitching, Shane Smith has been fairly steady and, in this start, he could very well give the Sox five to six quality innings if he can avoid the long ball and keep the walks in check.

So, what does that all add up to? It really feels like the Cardinals have the edge in this one—they come in better at getting runners on, have more consistent bats through their lineup, and their starting pitching stacks up just a bit better for this particular matchup. The White Sox have the home field and a few exciting pieces, but unless their offense catches fire, it’s tough to see them outdueling St. Louis, especially with the way the Cardinals string hits together. This one’s looking like a solid opportunity for the Cards to take game one and keep building momentum.

Chicago White Sox

St. Louis Cardinals

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