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San Diego Padres vs. Cincinnati Reds: Preview, Predictions and Picks for June 27, 2025

Updated on:
Jun 28, 2025 3:45 AM
The San Diego Padres, sitting second in the NL West with a 44-36 record, travel to Great American Ball Park to take on the Cincinnati Reds, who are 42-39 and fourth in the NL Central, in the first game of a 3-game series on Friday, June 27, 2025, at 7:10 PM. The Reds, 22-18 at home, look to capitalize on their winning record at Great American Ball Park, while the Padres aim to overcome their 19-22 road record. Expect a thrilling matchup between these two NL contenders.
San Diego Padres vs Cincinnati Reds

Current Odds

SD
CIN
Over
9.5
-101
Under
9.5
+100
SD
+1.5
-146
CIN
-1.5
+135
SD
ML
+140
CIN
ML
-145

Padres vs Reds statistics

Stat Padres Reds
Hits 661 (19th) 670 (16th)
Batting Average .248 (13th) .247 (14th)
Runs Batted In 312 (23rd) 356 (9th)
Runs 336 (21st) 372 (10th)
Home Runs 69 (26th) 88 (13th)
Walks 252 (19th) 274 (12th)
Stolen Bases 56 (Tied-17th) 64 (Tied-10th)
Strikeouts 561 (3rd) 704 (21st)
Pitches 11373 (24th) 11889 (16th)

Cincinnati Reds recent games

Game Date Opponent Result Score
6/25/25 vs New York Yankees L 7-1
6/24/25 vs New York Yankees W 5-4 F/11
6/23/25 vs New York Yankees W 6-1
6/22/25 @ St. Louis Cardinals W 4-1
6/21/25 @ St. Louis Cardinals L 6-5 F/11

San Diego Padres recent games

Game Date Opponent Result Score
6/25/25 vs Washington Nationals W 1-0
6/24/25 vs Washington Nationals W 4-3
6/23/25 vs Washington Nationals L 10-6
6/22/25 vs Kansas City Royals W 3-2
6/21/25 vs Kansas City Royals W 5-1

Cincinnati Reds injuries

  • Austin Hays (LF): 10-Day-IL
  • Jake Fraley (RF): Day-To-Day
  • Noelvi Marte (3B): 10-Day-IL
  • Graham Ashcraft (RP): 15-Day-IL
  • Carson Spiers (SP): 60-Day-IL

San Diego Padres injuries

  • Xander Bogaerts (SS): Day-To-Day
  • Logan Gillaspie (RP): 15-Day-IL
  • Robert Suarez (RP): suspension
  • Yu Darvish (SP): 60-Day-IL
  • Ethan Salas (C): Day-To-Day

Padres vs Reds game info

Type Info
Venue Great American Ball Park
Location Cincinnati, Ohio
First pitch Fri 7:10 PM
Temperature 90°
Chance of Rain 43%

Padres vs Reds predictions

The San Diego Padres are rolling into Great American Ball Park with some pretty intriguing storylines, especially when you look at their recent offensive sparks. Manny Machado, who’s been tearing up the league with a .298 average, looks like a great bet to put up another multi-hit game and drive in runs — as he’s been their most consistent force in the middle of the order. Luis Arraez isn’t flashy with home runs, but his contact skills are elite, so pencil him in for at least a couple of base knocks and maybe a run scored if the lineup clicks behind him. Meanwhile, keep your eyes on Fernando Tatis Jr.; with 15 homers already on the year and his power-speed combo, he’s always a threat to go deep or put pressure on the Reds’ defense with his legs. On the mound, Dylan Cease brings plenty of strikeout power and will probably rack up six or more Ks, but he’ll have to stay sharp with this Reds club.

Now, flipping over to the Cincinnati Reds side, you know everyone’s wondering if Elly De La Cruz can keep up his monster season. It wouldn’t be surprising to see him lace a double and swipe a bag, especially at home where he tends to feed off the energy. With 18 home runs and 55 RBI, De La Cruz has been the spark plug, and he’ll get some help from TJ Friedl, who’s batting .287 and could easily post a couple of hits and contribute both at the plate and in the field. And don’t sleep on Jake Fraley or Matt McLain—both are solid bets to reach base and create scoring chances in what’s quietly been a sneaky-deep Cincy lineup. The real X-factor could be Nick Martinez on the mound; if he can limit Padres sluggers and work into the middle innings, the Reds bullpen just might have a chance to slam the door.

Looking at how both teams match up, this feels like it could be a tightly contested game with some flair on both sides. The Padres have the star power, but their inconsistency on the road has been a major hurdle. The Cincinnati Reds, playing at Great American Ball Park where they have a strong home record, look poised to edge this one out, especially if De La Cruz and Friedl get rolling early. It might come down to who makes fewer mistakes on the mound, but the home-field advantage and a hungry Reds lineup give Cincinnati the slight edge in the opener. So if you’re looking to pick a side, leaning Reds wouldn’t be a bad call.

Cincinnati Reds

San Diego Padres

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