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Philadelphia 76ers vs. San Antonio Spurs: Preview, Predictions and Picks for March 21, 2025

Updated on:
Mar 21, 2025 9:13 PM
The San Antonio Spurs, holding a 29-39 overall record, look to bounce back at home against the Philadelphia 76ers, who sit at 23-46 overall, on Friday, March 21, 2025, at 8:00 PM at the Frost Bank Center. The 76ers currently lead the regular season series 1-0, but the Spurs will aim to even the score on their home court, where they've managed an 18-16 record so far this season.
Philadelphia 76ers vs San Antonio Spurs

Current Odds

PHI
SA
Over
252.5
-120
Under
253.5
+100
PHI
+2.5
-121
SA
+5.5
-105
PHI
ML
+189
SA
ML
+320

San Antonio Spurs recent games

Game Date Opponent Result Score
3/19/25 vs New York Knicks W 120-105
3/17/25 @ Los Angeles Lakers L 125-109
3/15/25 vs New Orleans Pelicans W 119-115
3/14/25 vs Charlotte Hornets L 145-134
3/12/25 vs Dallas Mavericks W 126-116

Philadelphia 76ers recent games

Game Date Opponent Result Score
3/19/25 @ Oklahoma City Thunder L 133-100
3/17/25 @ Houston Rockets L 144-137 OT
3/16/25 @ Dallas Mavericks W 130-125
3/14/25 vs Indiana Pacers L 112-100
3/12/25 @ Toronto Raptors L 118-105

San Antonio Spurs injuries

  • Charles Bassey (C): Out
  • De'Aaron Fox (PG): Out
  • Victor Wembanyama (C): Out
  • Riley Minix (F): Out

Philadelphia 76ers injuries

  • Adem Bona (C): Out
  • Andre Drummond (C): Out
  • Kyle Lowry (PG): Out
  • Kelly Oubre Jr. (SG): Out
  • Lonnie Walker IV (G): Out

76ers vs Spurs game info

Type Info
Venue Frost Bank Center
Location San Antonio, TX
Tip-off Fri 8:00 PM
TV FanDuel SN SW

76ers vs Spurs predictions

Anticipation is building as the Philadelphia 76ers prepare to take on the San Antonio Spurs. With Tyrese Maxey sidelined due to a back sprain, the 76ers will likely lean on the talents of Jared Butler, who is expected to light up the court with his scoring and playmaking ability. Butler should be a key contributor, potentially delivering around 18 points and dishing out seven assists, guiding the offense in Maxey's absence. Quentin Grimes is another player to watch out for; he has the knack for filling up the stat sheet and may surprise us with close to 20 points, as well as providing solid support on the boards. Then there's Justin Edwards, the wild card, who could bolster the lineup with his scrappy play and effective scoring. Picture Edwards sneaking in 12 to 13 points while also grinding hard on the defensive end.

On the other side, the San Antonio Spurs will be without standout rookie Victor Wembanyama, which means that others will have to step up to fill the void. Jeremy Sochan has been steadily emerging as a versatile force, and I wouldn't be surprised if he showcases his ability to crash the boards and make plays happen, flirting with a double-double. Devin Vassell looks poised to be a major scoring threat—given his recent form, he could easily rack up 18 to 19 points tonight. Chris Paul, the seasoned vet, will undoubtedly bring his basketball IQ and playmaking prowess to the table, setting up his teammates and probably chipping in a modest 10 points himself. Spurs fans will be eager to see how Stephon Castle adapts to increased pressure, as he'll likely be tasked with providing a spark both offensively and defensively.

With both teams missing key players, the balance could tip in favor of whoever finds that next-man-up mentality. The Spurs, with a solid home record, are undoubtedly hoping that their depth and veterans like Chris Paul will give them the edge. Meanwhile, the 76ers will aim to exploit their younger roster's potential to create fast-paced, unpredictable plays to keep the Spurs on their toes. In the end, however, the scales slightly tilt toward the San Antonio Spurs. Their combination of experience, home-court advantage, and roster depth could propel them to secure a hard-fought victory in a game that promises plenty of intrigue and drama. What do you think—are you Team Sixers or backing the Spurs?

San Antonio Spurs

No
San Antonio Spurs
players

Philadelphia 76ers

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Philadelphia 76ers
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