Up arrow
NFL
Games

Miami Dolphins vs. Indianapolis Colts: Preview, Predictions and Picks for September 7, 2025

Updated on:
Jul 15, 2025 1:06 PM
This Sunday, September 7th, 2025, the Miami Dolphins hit the road to take on the Indianapolis Colts at Lucas Oil Stadium, with both teams looking to kick off their season on a high note. With neither squad having played a regular season game yet, expectations are high as they clash in this AFC showdown. Will the Dolphins' fresh legs prove too much for the Colts on their home turf?
Miami Dolphins vs Indianapolis Colts

Current Odds

MIA
IND
Over
46.5
-105
Under
46.0
+105
MIA
+1.0
-114
IND
+1.0
-104
MIA
ML
-102
IND
ML
+103

Indianapolis Colts recent games

Game Date Opponent Result Score
1/5/25 vs Jacksonville Jaguars W 26-23 OT
12/29/24 @ New York Giants L 45-33
12/22/24 vs Tennessee Titans W 38-30
12/15/24 @ Denver Broncos L 31-13
12/1/24 @ New England Patriots W 25-24

Miami Dolphins recent games

Game Date Opponent Result Score
1/5/25 @ New York Jets L 32-20
12/29/24 @ Cleveland Browns W 20-3
12/22/24 vs San Francisco 49ers W 29-17
12/15/24 @ Houston Texans L 20-12
12/8/24 vs New York Jets W 32-26 OT

Indianapolis Colts injuries

  • Jaylon Carlies (LB): Questionable
  • Jaylon Jones (CB): Questionable
  • Anthony Richardson Sr. (QB): Questionable
  • Zaire Franklin (LB): Questionable
  • Michael Pittman Jr. (WR): Questionable

Miami Dolphins injuries

  • James Daniels (G): Questionable
  • Nick Westbrook-Ikhine (WR): Questionable
  • Tyreek Hill (WR): Questionable
  • Tahj Washington (WR): Questionable
  • Jaelan Phillips (LB): Questionable

Dolphins vs Colts game info

Type Info
Venue Lucas Oil Stadium
Location Indianapolis, IN
Kickoff Sun 1:00 PM
TV CBS

Dolphins vs Colts predictions

When you look at the Miami Dolphins heading into their matchup at Lucas Oil Stadium, a few names instantly pop out. Tua Tagovailoa seems poised to put up solid numbers, and I’d expect him to flirt with that 230-yard mark through the air, likely connecting for at least one or two touchdowns. Tyreek Hill is always a game-changer, and this looks like another spot where he racks up chunk yardage—think about 60 or so yards with a good shot at finding the end zone. Don’t sleep on De’Von Achane, either; he should be able to keep the Colts defense honest with his explosiveness, and it wouldn’t surprise me if he breaks off a couple of eye-catching runs and chips in some catches out of the backfield as well.

For Indy, the offensive story feels like it will run straight through Jonathan Taylor. I’d expect him to set the tempo with north of 70 rushing yards and maybe hit paydirt once. The quarterback situation is always one to monitor for the Colts, but whether it’s Daniel Jones or Anthony Richardson taking snaps, neither should be expected to light up the stat sheet—think efficient but conservative passing with around 100 yards, maybe a touchdown toss at best. Michael Pittman and Josh Downs are the primary targets to watch; both should get their fair share of looks, and one of them probably crosses the 40-yard mark, making them intriguing X-factors.

As these two teams go toe-to-toe, there’s every reason to believe this will be a battle that comes down to a handful of key plays. The Colts, slight favorites at home, definitely have the ground game to control the clock, but the Dolphins’ speed and firepower on offense give them a real puncher’s chance. With Tua distributing the ball and Hill capable of flipping the field in seconds, I see Miami holding the edge in playmaking, while the Colts counter with grit and steady production. When it comes down to it, I’m leaning towards the Colts pulling out a close win at home—but it’s going to be tight, and nobody should be shocked if the Dolphins make it interesting right to the final whistle.

Indianapolis Colts

Miami Dolphins

More Games