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Denver Broncos vs. San Francisco 49ers: Preview, Predictions and Picks for August 9, 2025

Updated on:
Aug 5, 2025 3:42 AM
On Saturday, August 9, 2025, the Denver Broncos will travel to Levi's Stadium to take on the San Francisco 49ers in a highly anticipated matchup. Both teams are looking to make a statement in their early season tilt, with each side currently sitting at 0-0 on the young season. Expect a thrilling contest as these two franchises clash under the lights at 8:30 PM.
Denver Broncos vs San Francisco 49ers

Current Odds

DEN
SF
Over
34.5
-110
Under
34.5
-105
DEN
-6.0
-104
SF
+6.0
-110
DEN
ML
-255
SF
ML
+220

San Francisco 49ers recent games

Game Date Opponent Result Score
1/5/25 @ Arizona Cardinals L 47-24
12/30/24 vs Detroit Lions L 40-34
12/22/24 @ Miami Dolphins L 29-17
12/12/24 vs Los Angeles Rams L 12-6
12/8/24 vs Chicago Bears W 38-13

Denver Broncos recent games

Game Date Opponent Result Score
1/12/25 @ Buffalo Bills L 31-7
1/5/25 vs Kansas City Chiefs W 38-0
12/28/24 @ Cincinnati Bengals L 30-24 OT
12/19/24 @ Los Angeles Chargers L 34-27
12/15/24 vs Indianapolis Colts W 31-13

San Francisco 49ers injuries

  • Isaac Guerendo (RB): Questionable
  • Jordan James (RB): Questionable
  • Deommodore Lenoir (CB): Questionable
  • Jauan Jennings (WR): Questionable
  • Brandon Aiyuk (WR): Out

Denver Broncos injuries

  • Drew Sanders (LB): Questionable
  • Michael Burton (FB): Questionable
  • Dre Greenlaw (LB): Questionable
  • Johnny Walker Jr. (LB): Injured Reserve
  • A.T. Perry (WR): Out

Broncos vs 49ers game info

Type Info
Venue Levi's Stadium
Location Santa Clara, CA
Kickoff Sat 8:30 PM
TV KUSA-TV (9NEWS)
Temperature 84°
Chance of Rain 0%

Broncos vs 49ers predictions

Looking at the Denver Broncos roster heading into this matchup, there’s a ton of curiosity about how their offensive pieces will mesh at Levi’s Stadium. Quarterback Russell Wilson remains someone you just can’t count out; his improvisational style and deep ball accuracy can always spark something, especially with a healthy Jerry Jeudy stretching the field. Javonte Williams, shaking off last season’s injury bug, seems primed to be a difference-maker—expect him to get plenty of touches both on the ground and through the air. Of course, eyes are on the Broncos’ defense, too; Pat Surtain II locking onto Deebo Samuel could be a fun battle to watch, and if Baron Browning gets loose off the edge, pressure could make things tricky for the Niners’ QB.

Switching gears to San Francisco, there’s always that sense of expectation with their versatile offense. Brock Purdy’s poise under pressure turned heads last year, and with the odds putting the 49ers as slight favorites, there’s every reason to think they’ll trust him to attack a Denver secondary that can be aggressive. Christian McCaffrey, of course, is the chess piece who can tilt the field at any time, so if he gets rolling early—slipping tackles, catching passes, keeping the defense honest—the home crowd at Levi’s should have plenty to cheer about. Then factor in Brandon Aiyuk and Deebo Samuel carving out space, it just feels like the Niners will find ways to move the ball even when things get tight.

Putting it all together, you have what could be a real back-and-forth showdown, but I’m leaning toward the 49ers to edge this one out. The home field, paired with that slightly more explosive offense and tough defense, give them just enough of an advantage. Don’t be surprised if it’s a close call until late, but I’d put my money on San Francisco pulling away in the second half—maybe by a touchdown, maybe less, but enough to cover that -2.5 spread. What do you think: upset brewing, or does the home team hold serve?

San Francisco 49ers

No
San Francisco 49ers
players

Denver Broncos

No
Denver Broncos
players

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