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Cleveland Guardians vs. San Diego Padres: Preview, Predictions and Picks for April 2, 2025

Updated on:
Apr 2, 2025 5:37 PM
On Wednesday, April 2, 2025, the San Diego Padres will host the Cleveland Guardians at Petco Park, looking to extend their 6-game home winning streak. The Padres, unbeaten so far this season, aim to add to their 2-0 series lead against the Guardians, who are seeking to bounce back from a 2-3 start to their campaign.
Cleveland Guardians vs San Diego Padres

Current Odds

CLE
SD
Over
7.5
+1500
Under
7.5
-500
CLE
+2.5
+1300
SD
-2.5
-526
CLE
ML
+13000
SD
ML
-10000

Guardians vs Padres statistics

Stat Guardians Padres
Hits 36 (20th) 55 (Tied-2nd)
Batting Average .224 (17th) .299 (2nd)
Runs Batted In 18 (Tied-20th) 30 (6th)
Runs 18 (21st) 31 (6th)
Home Runs 7 (Tied-10th) 4 (Tied-20th)
Walks 17 (Tied-16th) 24 (Tied-5th)
Stolen Bases 0 (Tied-28th) 13 (2nd)
Strikeouts 40 (Tied-16th) 35 (Tied-25th)
Pitches 778 (11th) 804 (10th)

San Diego Padres recent games

Game Date Opponent Result Score
4/1/25 vs Cleveland Guardians W 7-0
3/31/25 vs Cleveland Guardians W 7-2
3/30/25 vs Atlanta Braves W 5-0
3/29/25 vs Atlanta Braves W 1-0
3/28/25 vs Atlanta Braves W 4-3

Cleveland Guardians recent games

Game Date Opponent Result Score
4/1/25 @ San Diego Padres L 7-0
3/31/25 @ San Diego Padres L 7-2
3/30/25 @ Kansas City Royals W 6-2
3/29/25 @ Kansas City Royals L 4-3
3/27/25 @ Kansas City Royals W 7-4 F/10

San Diego Padres injuries

  • Matt Waldron (SP): 15-Day-IL
  • Jhony Brito (RP): 15-Day-IL
  • Bryan Hoeing (RP): 15-Day-IL
  • Yu Darvish (SP): 15-Day-IL
  • Sean Reynolds (RP): 15-Day-IL

Cleveland Guardians injuries

  • Jake Anchia (C): Day-To-Day
  • Slade Cecconi (SP): 15-Day-IL
  • George Valera (RF): Day-To-Day
  • Erik Sabrowski (RP): 15-Day-IL
  • Chase DeLauter (RF): Day-To-Day

Guardians vs Padres game info

Type Info
Venue Petco Park
Location San Diego, California
First pitch Wed 4:10 PM
Temperature 60°
Chance of Rain 7%

Guardians vs Padres predictions

As the Cleveland Guardians prepare to face off against the San Diego Padres, all eyes will be on their key players, like Steven Kwan and Kyle Manzardo. Kwan, carrying an impressive .368 batting average, is expected to keep up his reliable performance, likely leading the charge with around a hit per game. Similarly, Manzardo's penchant for power at the plate could see him adding another homer to his record, making him a critical component of the Guardians' lineup. In terms of pitching, Ben Lively is likely to carry much of the load, with his mix of pitches and strategic approach potentially helping him navigate through the Padres' formidable batting order. However, he'll need strong backing from the Guardians' defense to contain the Padres' explosive hitters and maintain a fighting chance.

Speaking of the Padres, there's no ignoring Fernando Tatis Jr., who's been on a tear this season with a stellar .409 batting average. His keen eye for pitches makes him a constant threat, whether it’s hitting one out of the park or making a clever advance on the bases. Alongside Tatis, we can expect Xander Bogaerts to be a significant offensive weapon. With his ability to get on base and bring runners around, he’s a steady contributor to the lineup’s successes. Meanwhile, over on the mound, Dylan Cease will be playing a crucial role in keeping the Guardian hitters at bay. Armed with a diverse array of pitches and surgical precision, Cease is likely to rack up a few strikeouts, offering the Padres a solid chance to extend their ongoing win streak.

When it comes down to who might clinch the victory, the odds seem to tilt in favor of the San Diego Padres. Their impressive undefeated streak at home, powered by a combination of offensive depth and tactical pitching, gives them a slight edge over the Guardians. The Padres seem to be firing on all cylinders, both at the plate and on the field, bringing an abundance of energy and chemistry to Petco Park. While the Guardians certainly possess the talent and tenacity to potentially disrupt this momentum, the prevailing opinion is that the Padres have what it takes to continue their winning groove. What do you think? Will the Padres keep rolling, or can the Guardians flip the script?

San Diego Padres

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