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Cincinnati Reds vs. St. Louis Cardinals: Preview, Predictions and Picks for June 20, 2025

Updated on:
Jun 21, 2025 12:43 AM
The St. Louis Cardinals, sitting at 40-35, welcome the Cincinnati Reds, holding a 39-36 record, to Busch Stadium on Friday, June 20, 2025. The series is currently tied 2-2, with the Cardinals having a strong 22-14 home record, while the Reds have a .500 road record at 19-19. First pitch is set for 7:15 PM.
Cincinnati Reds vs St. Louis Cardinals

Current Odds

CIN
STL
Over
9.0
-105
Under
9.5
-120
CIN
+1.5
-120
STL
-1.5
+110
CIN
ML
+167
STL
ML
-185

Reds vs Cardinals statistics

Stat Reds Cardinals
Hits 625 (14th) 657 (3rd)
Batting Average .248 (14th) .257 (3rd)
Runs Batted In 337 (7th) 335 (8th)
Runs 350 (8th) 353 (7th)
Home Runs 84 (12th) 72 (Tied-22nd)
Walks 260 (Tied-8th) 241 (17th)
Stolen Bases 61 (Tied-10th) 41 (24th)
Strikeouts 653 (Tied-24th) 589 (11th)
Pitches 10988 (14th) 11112 (9th)

St. Louis Cardinals recent games

Game Date Opponent Result Score
6/19/25 @ Chicago White Sox W 8-6 F/10
6/19/25 @ Chicago White Sox W 5-4
6/17/25 @ Chicago White Sox W 12-2
6/15/25 @ Milwaukee Brewers L 3-2
6/14/25 @ Milwaukee Brewers W 8-5

Cincinnati Reds recent games

Game Date Opponent Result Score
6/19/25 vs Minnesota Twins L 12-5
6/18/25 vs Minnesota Twins W 4-2 F/6
6/17/25 vs Minnesota Twins W 6-5
6/15/25 @ Detroit Tigers W 8-4
6/14/25 @ Detroit Tigers W 11-1

St. Louis Cardinals injuries

  • Drew Rom (SP): Day-To-Day
  • Zack Thompson (RP): 60-Day-IL
  • Packy Naughton (RP): Day-To-Day
  • Victor Santos (RP): Day-To-Day
  • Cooper Hjerpe (SP): Day-To-Day

Cincinnati Reds injuries

  • Jeimer Candelario (3B): 10-Day-IL
  • Hunter Greene (SP): 15-Day-IL
  • Austin Hays (LF): 10-Day-IL
  • Noelvi Marte (3B): 10-Day-IL
  • Graham Ashcraft (RP): 15-Day-IL

Reds vs Cardinals game info

Type Info
Venue Busch Stadium
Location St. Louis, Missouri
First pitch Fri 7:15 PM
Temperature 92°
Chance of Rain 0%

Reds vs Cardinals predictions

If you’re keeping an eye on the Cincinnati Reds in this opener against the St. Louis Cardinals, there are a few bats absolutely worth watching. Elly De La Cruz continues to look like a game-changer—don’t be surprised if he comes through with a multi-hit game, possibly adding a homer and a steal to his stat line. TJ Friedl’s been quietly consistent, too, and with his knack for finding his way on base, I could see him notching a pair of hits and making things happen on the basepaths. With Will Benson and Jake Fraley rounding out the lineup and both capable of getting on base and swiping bags, the Reds’ offense definitely feels like it has sneaky potential to kickstart some rallies early in this one.

Now flipping over to the St. Louis Cardinals, Brendan Donovan’s been straight-up raking lately, so it’s hard not to pencil him in for at least a couple hits tonight. Add in the consistent bat of Alec Burleson—who could easily notch a hit or two and drive in a run—and you’ve got the makings of a lineup that can string together big innings. Nolan Arenado, even if he’s not mashing homers every night, always threatens to drive one into the gap, and with Willson Contreras flashing his power and run-producing ways, the Cardinals’ order looks just as dangerous. If you’re a fan of solid contact and smart baseball, this St. Louis club tends to deliver at home, especially with Masyn Winn’s ability to spark the lineup from the lower third.

So, who’s got the edge in this NL Central showdown? Looking at both squads, the Cardinals seem to have a slight advantage, especially playing at Busch Stadium where their offense tends to shine—and with Andre Pallante on the bump, that only boosts their chances. But hey, the Reds have shown they’re scrappy and never really out of a game. Still, the safe money feels like it’s on St. Louis pulling out a close one in what should be a tight, back-and-forth series opener. What do you think—are the Cardinals primed to defend home turf, or will the Reds steal the show?

St. Louis Cardinals

Cincinnati Reds

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