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Chicago White Sox vs. Boston Red Sox: Preview, Predictions and Picks for April 21, 2025

Updated on:
Apr 21, 2025 12:16 PM
The Boston Red Sox look to capitalize on their 2-1 series lead as they host the Chicago White Sox at Fenway Park on Monday, April 21, 2025. With a strong 6-4 home record, the Red Sox aim to extend their advantage over the struggling White Sox, who have struggled on the road with a 1-8 record. A win would give the Red Sox a commanding lead in the series.
Chicago White Sox vs Boston Red Sox

Current Odds

CHW
BOS
Over
7.0
+102
Under
6.5
+100
CHW
+1.5
+333
BOS
-2.5
+240
CHW
ML
+2800
BOS
ML
-1100

White Sox vs Red Sox statistics

Stat White Sox Red Sox
Hits 134 (30th) 195 (4th)
Batting Average .198 (30th) .246 (12th)
Runs Batted In 66 (29th) 100 (6th)
Runs 68 (Tied-27th) 104 (7th)
Home Runs 16 (Tied-24th) 23 (Tied-13th)
Walks 66 (23rd) 86 (5th)
Stolen Bases 16 (Tied-16th) 25 (Tied-6th)
Strikeouts 176 (Tied-11th) 217 (29th)
Pitches 2958 (29th) 3510 (2nd)

Boston Red Sox recent games

Game Date Opponent Result Score
4/20/25 vs Chicago White Sox L 8-4
4/19/25 vs Chicago White Sox W 4-3 F/10
4/18/25 vs Chicago White Sox W 10-3
4/16/25 @ Tampa Bay Rays W 1-0
4/15/25 @ Tampa Bay Rays W 7-4

Chicago White Sox recent games

Game Date Opponent Result Score
4/20/25 @ Boston Red Sox W 8-4
4/19/25 @ Boston Red Sox L 4-3 F/10
4/18/25 @ Boston Red Sox L 10-3
4/17/25 vs Athletics L 8-0
4/16/25 vs Athletics L 3-1

Boston Red Sox injuries

  • Brayan Bello (SP): 15-Day-IL
  • Seby Zavala (C): Day-To-Day
  • Richard Fitts (SP): 15-Day-IL
  • Lucas Giolito (SP): 15-Day-IL
  • Connor Wong (C): 10-Day-IL

Chicago White Sox injuries

  • Chase Meidroth (2B): Day-To-Day
  • Mike Tauchman (RF): 10-Day-IL
  • Korey Lee (C): 10-Day-IL
  • Fraser Ellard (RP): 15-Day-IL
  • Josh Rojas (3B): 10-Day-IL

White Sox vs Red Sox game info

Type Info
Venue Fenway Park
Location Boston, Massachusetts
First pitch Mon 11:10 AM
TV MLBN
Temperature 53°
Chance of Rain 0%

White Sox vs Red Sox predictions

When it comes to the Chicago White Sox taking the field, Andrew Benintendi often shines through with his consistent approach at the plate. This game, he might be one to watch with potential to round the bases a couple of times. Meanwhile, Andrew Vaughn has a knack for driving in runs, and we might see him adding to his RBI tally as he faces off against the Boston pitching. Despite Lenyn Sosa holding the highest batting average on the team at .271, the White Sox are struggling as a whole, and it's evident in their challenging road record of 1-8. On the mound, Jonathan Cannon will likely need to bring his A-game, as the rest of the team's pitching stats do not inspire overwhelming confidence. It's going to take some real grit and timely hitting to make a strong showing against a formidable opponent like Boston.

Shifting gears to the Boston Red Sox, it's hard not to talk about Trevor Story. Whether he's at bat or flashing some leather in the field, he's the player who can turn the tide with a timely home run or a pivotal RBI. Pair that with Alex Bregman’s potential contributions—seeing how he’s been racking up those RBIs—and you’ve got a compelling duo making things happen for Boston. Don’t overlook Rafael Devers either; he's a player who consistently helps set the table with his ability to get on base. With Walker Buehler on the mound, the Red Sox have a real opportunity to keep the pressure on the White Sox and potentially control the game early on, with Buehler expected to limit runs and zip some strikeouts past Chicago's hitters.

Predicting the winner in this face-off isn't easy, but if current trends and player capabilities are anything to go by, Boston seems poised for a strong performance at Fenway Park. Given their higher batting average, a deeper lineup in terms of run contribution, and favorable odds, the Boston Red Sox seem likely to clinch the series by taking another win over the White Sox. With their current momentum and home field advantage, the Red Sox could very well leave the bustling crowd at Fenway celebrating yet another victory. So, if you’re putting on your fan cap, it might be wise to rally behind Boston in this matchup.

Boston Red Sox

Chicago White Sox

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