Up arrow
MLB
Games

Chicago Cubs vs. St. Louis Cardinals: Preview, Predictions and Picks for June 23, 2025

Updated on:
Jun 24, 2025 2:46 AM
The Chicago Cubs, sitting atop the NL Central with a 46-31 record, head to Busch Stadium to take on the St. Louis Cardinals in a crucial four-game series. The Cardinals, currently third in the division with a 42-36 overall record, look to capitalize on their strong 24-15 home record. On Monday, June 23, the Cubs will send their 21-16 road record into battle against the Cardinals at 7:45 PM.
Chicago Cubs vs St. Louis Cardinals

Current Odds

CHC
STL
Over
9.0
+102
Under
9.0
-110
CHC
-1.5
+150
STL
+1.5
-154
CHC
ML
-112
STL
ML
+107

Cubs vs Cardinals statistics

Stat Cubs Cardinals
Hits 677 (5th) 676 (6th)
Batting Average .254 (9th) .255 (8th)
Runs Batted In 409 (2nd) 346 (9th)
Runs 417 (2nd) 366 (9th)
Home Runs 113 (Tied-3rd) 74 (24th)
Walks 269 (Tied-8th) 252 (17th)
Stolen Bases 91 (3rd) 43 (Tied-22nd)
Strikeouts 611 (10th) 612 (11th)
Pitches 11689 (5th) 11565 (9th)

St. Louis Cardinals recent games

Game Date Opponent Result Score
6/22/25 vs Cincinnati Reds L 4-1
6/21/25 vs Cincinnati Reds W 6-5 F/11
6/20/25 vs Cincinnati Reds W 6-1
6/19/25 @ Chicago White Sox W 8-6 F/10
6/19/25 @ Chicago White Sox W 5-4

Chicago Cubs recent games

Game Date Opponent Result Score
6/22/25 vs Seattle Mariners L 14-6
6/21/25 vs Seattle Mariners W 10-7
6/20/25 vs Seattle Mariners L 9-4
6/19/25 vs Milwaukee Brewers L 8-7
6/17/25 vs Milwaukee Brewers W 5-3

St. Louis Cardinals injuries

  • Drew Rom (SP): Day-To-Day
  • Ivan Herrera (C): 10-Day-IL
  • Zack Thompson (RP): 60-Day-IL
  • Packy Naughton (RP): Day-To-Day
  • Victor Santos (RP): Day-To-Day

Chicago Cubs injuries

  • Eli Morgan (RP): 60-Day-IL
  • Porter Hodge (RP): 15-Day-IL
  • Javier Assad (SP): 60-Day-IL
  • Shota Imanaga (SP): 15-Day-IL
  • Matthew Boyd (SP): Day-To-Day

Cubs vs Cardinals game info

Type Info
Venue Busch Stadium
Location St. Louis, Missouri
First pitch Mon 7:45 PM
Temperature 94°
Chance of Rain 0%

Cubs vs Cardinals predictions

The Chicago Cubs roll into Busch Stadium with plenty of momentum and some hot bats ready to make noise. I’m looking at Kyle Tucker, who’s been a steady force this season—don’t be surprised if he racks up multiple hits in this opener, maybe even a big RBI to get things going early. Pete Crow-Armstrong feels like a wild card here; with his power and knack for coming through in key moments, he could put one over the fence and add a stolen base just to remind everyone how electric he is. Seiya Suzuki, too, has been quietly productive; I can definitely see him chipping in with both hits and runs, really pushing the Cardinals’ pitching staff to work for every out.

Now, the St. Louis Cardinals aren’t just going to let the Cubs have their way. Brendan Donovan comes in hitting over .300—it just feels right to see him slap at least one or two hits and maybe cross the plate himself, setting the tone for the lineup. Nolan Arenado may not be leading the league in homers, but you can almost sense when he’s due for a clutch base knock or a timely double. Willson Contreras is always a threat, and with his recent ability to drive in runs, I wouldn’t be surprised if he tallies another RBI in front of the home crowd.

When it comes to how this game might shake out, it’s bound to be close. Busch Stadium has been a good home for the Cardinals this year, but the Cubs’ combo of power and speed gives them a real edge, especially with Ben Brown looking sharp on the mound. Unless the Cardinals’ bats wake up early, I like the Cubs to take the opener—probably in a tight one, but their energy and balanced lineup may just give them the edge they need to come out on top. What do you think: is this game destined for some late-inning drama?

St. Louis Cardinals

Chicago Cubs

More Games