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Chicago Cubs vs. Cincinnati Reds: Preview, Predictions and Picks for May 23, 2025

Updated on:
May 23, 2025 6:52 PM
The Cincinnati Reds aim to prolong their 4-game home streak as they host the Chicago Cubs at Great American Ball Park on Friday, May 23, 2025, at 6:40 PM. The Reds, holding a 13-12 home record, will face the NL Central-leading Cubs, who have a 15-10 road record. Expect a thrilling matchup between these divisional rivals.
Chicago Cubs vs Cincinnati Reds

Current Odds

CHC
CIN
Over
8.5
+100
Under
9.5
-110
CHC
+1.5
+300
CIN
+1.5
-165
CHC
ML
+750
CIN
ML
+103

Cubs vs Reds statistics

Stat Cubs Reds
Hits 455 (1st) 412 (Tied-12th)
Batting Average .261 (4th) .241 (19th)
Runs Batted In 286 (1st) 220 (Tied-10th)
Runs 293 (1st) 228 (11th)
Home Runs 69 (5th) 53 (Tied-13th)
Walks 190 (4th) 175 (Tied-10th)
Stolen Bases 63 (3rd) 52 (4th)
Strikeouts 398 (12th) 457 (27th)
Pitches 7718 (1st) 7413 (14th)

Cincinnati Reds recent games

Game Date Opponent Result Score
5/21/25 @ Pittsburgh Pirates L 3-1
5/20/25 @ Pittsburgh Pirates L 1-0
5/19/25 @ Pittsburgh Pirates W 7-1
5/18/25 vs Cleveland Guardians W 3-1
5/17/25 vs Cleveland Guardians W 4-1

Chicago Cubs recent games

Game Date Opponent Result Score
5/21/25 @ Miami Marlins W 2-1
5/20/25 @ Miami Marlins W 14-1
5/19/25 @ Miami Marlins L 8-7
5/18/25 vs Chicago White Sox W 6-2
5/17/25 vs Chicago White Sox W 7-3

Cincinnati Reds injuries

  • Hunter Greene (SP): 15-Day-IL
  • Jake Fraley (RF): 10-Day-IL
  • Wade Miley (SP): Day-To-Day
  • Rhett Lowder (SP): 15-Day-IL
  • Christian Encarnacion-Strand (1B): 10-Day-IL

Chicago Cubs injuries

  • Ryan Brasier (RP): 15-Day-IL
  • Tyson Miller (RP): 60-Day-IL
  • Brandon Birdsell (RP): Day-To-Day
  • Porter Hodge (RP): 15-Day-IL
  • Javier Assad (SP): 60-Day-IL

Cubs vs Reds game info

Type Info
Venue Great American Ball Park
Location Cincinnati, Ohio
First pitch Fri 6:40 PM
Temperature 66°
Chance of Rain 0%

Cubs vs Reds predictions

If you’re keeping an eye on the Chicago Cubs, this matchup at Great American Ball Park comes packed with intrigue, especially when you look at what their lineup’s been doing this season. Matthew Boyd is set to take the mound for the Cubs and I think he’s good for at least five innings of solid work, probably giving up a couple runs but racking up a respectable strikeout tally. Turning to the bats, keep a lookout for Nico Hoerner, who’s been seeing the ball well—expect another multi-hit night from him and some table-setting magic. Kyle Tucker’s power keeps making noise, so it wouldn’t surprise me if he goes yard or at least delivers a couple of clutch RBIs. And with Seiya Suzuki’s knack for driving in runs, I’d be shocked if he didn’t factor into the Cubs’ scoring in some way.

Flip the script, and the Cincinnati Reds have a reason to feel confident coming in with a four-game home win streak. Hunter Greene should give them a sturdy start, mixing his heat and wicked slider to keep Cubs hitters honest, and I’d peg him for at least six strikeouts and a decent chance to limit big damage. Gavin Lux is a name to keep circling—he’s had a knack for getting on base lately, and I can see him chipping in a couple of hits. The X-factor, though, is Elly De La Cruz; he’s always one swing away from a game-changing moment and could absolutely swipe a base or two if he gets on. Don’t count out Matt McLain or TJ Friedl to make some noise either, especially with both showing a knack for driving in runs lately.

When the dust settles, this one feels like it could go the distance, but with the Reds playing hot at home and getting contributions throughout the lineup, I’m leaning toward Cincinnati to pull off a close win. Their pitching’s been just sharp enough lately, and with Greene setting the tone and some timely offense chipping in, they just have a little extra spark. But hey, that’s what makes MLB so fun—the only thing predictable is the unpredictability. Got your score predictions ready?

Cincinnati Reds

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