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Baltimore Orioles vs. Cleveland Guardians: Preview, Predictions and Picks for July 22, 2025

Updated on:
Jul 22, 2025 1:22 PM
The Baltimore Orioles look to even the series against the Cleveland Guardians on Tuesday at Progressive Field, after falling short in game one. The Guardians will aim to build on their 1-0 series lead, led by their 23-24 home record. First pitch is set for 6:40 PM on July 22, 2025.
Baltimore Orioles vs Cleveland Guardians

Current Odds

BAL
CLE
Over
7.5
-125
Under
8.5
-120
BAL
+1.0
-105
CLE
-1.5
+141
BAL
ML
+144
CLE
ML
-133

Orioles vs Guardians statistics

Stat Orioles Guardians
Hits 791 (24th) 728 (30th)
Batting Average .239 (23rd) .225 (29th)
Runs Batted In 385 (24th) 366 (26th)
Runs 407 (Tied-23rd) 381 (26th)
Home Runs 115 (12th) 105 (Tied-19th)
Walks 267 (28th) 314 (18th)
Stolen Bases 73 (15th) 79 (10th)
Strikeouts 865 (Tied-20th) 812 (13th)
Pitches 14358 (23rd) 14272 (24th)

Cleveland Guardians recent games

Game Date Opponent Result Score
7/21/25 vs Baltimore Orioles W 10-5
7/20/25 vs Athletics W 8-2
7/19/25 vs Athletics L 8-2
7/18/25 vs Athletics W 8-6
7/13/25 @ Chicago White Sox W 6-5 F/10

Baltimore Orioles recent games

Game Date Opponent Result Score
7/21/25 @ Cleveland Guardians L 10-5
7/20/25 @ Tampa Bay Rays W 5-3
7/19/25 @ Tampa Bay Rays L 4-3
7/18/25 @ Tampa Bay Rays L 11-1
7/13/25 vs Miami Marlins L 11-1

Cleveland Guardians injuries

  • Tanner Burns (SP): Day-To-Day
  • Trevor Stephan (RP): 60-Day-IL
  • Gabriel Arias (SS): 10-Day-IL
  • Chase DeLauter (RF): Day-To-Day
  • Lane Thomas (CF): 10-Day-IL

Baltimore Orioles injuries

  • Zach Eflin (SP): 15-Day-IL
  • Sam Basallo (C): Day-To-Day
  • Keegan Akin (RP): 15-Day-IL
  • Chadwick Tromp (C): 10-Day-IL
  • Jud Fabian (CF): Day-To-Day

Orioles vs Guardians game info

Type Info
Venue Progressive Field
Location Cleveland, Ohio
First pitch Tue 6:40 PM
Temperature 77°
Chance of Rain 0%

Orioles vs Guardians predictions

The Baltimore Orioles roll into Progressive Field looking to even up the series, and there are a few names on this lineup worth keeping your eye on. Gunnar Henderson has been the steadiest bat for the Orioles so far—don’t be surprised if he flashes his power with an extra-base hit or two and maybe gets on base a couple of times. Tyler O’Neill, with his knack for timely hits, can chip in an RBI and has a shot at crossing the plate himself if the guys in front of him set the table. Jordan Westburg is another spark plug; he’s due for at least a hit and should factor into the scoring with solid at-bats and maybe a stolen base if things break right.

Switching over to the Cleveland Guardians, this team seems primed for a big night offensively, especially with Jose Ramirez at the heart of the lineup. Ramirez is always a threat—expect to see him slap a few hits, maybe drive in a pair, and he could even send one over the fence. Steven Kwan, with his contact-heavy approach, has been one of the more reliable table-setters in baseball, so look for him to rack up a couple of hits and score at least once. And you can’t forget about Carlos Santana and Kyle Manzardo, who both have a great chance of producing multiples hits or driving in runs, making Cleveland’s middle order look extra dangerous in this matchup.

All things considered, the Guardians seem to have the edge in this one—playing at home and riding some strong performances from their star hitters. With their lineup getting on base and applying pressure, along with Joey Cantillo’s ability to rack up strikeouts and limit damage on the mound, it feels like Cleveland’s game to lose. I’m predicting the Guardians take game two and put themselves in a strong spot for the rest of the series. But hey, in baseball, you never really know—one big swing or a surprise outing from a pitcher can turn everything on its head. What’s your call?

Cleveland Guardians

Baltimore Orioles

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